Evidence map›Paper›PMID 34599400›Full record

SynthesisLasers in medical science2022

Photobiomodulation impacts the levels of inflammatory mediators during orthodontic tooth movement? A systematic review with meta-analysis.

Caio Luiz Bitencourt Reis, Taíssa Cássia de Souza Furtado, Wendes Dias Mendes, Mirian Aiko Nakane Matsumoto, Sandra Yasuyo Fukada Alves, Maria Bernadete Sasso Stuani, Maria Cristina Borsatto, Silmara Aparecida Milori Corona

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Immune Responses in Orthodontic Treatment.Advances in experimental medicine and biology · 2026
    Review
  5. Review
  6. The Role of Cytokines in Orthodontic Tooth Movement.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caio Luiz Bitencourt ReisDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café, S/N, Subsetor Oeste, Ribeirão Preto, São Paulo, Brazil. caioluizreis@usp.br.ORCID http://orcid.org/0000-0003-0606-1632
Taíssa Cássia de Souza FurtadoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café, S/N, Subsetor Oeste, Ribeirão Preto, São Paulo, Brazil.
Wendes Dias MendesDepartment of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Mirian Aiko Nakane MatsumotoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café, S/N, Subsetor Oeste, Ribeirão Preto, São Paulo, Brazil.
Sandra Yasuyo Fukada AlvesDepartment of Bio Molecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
Maria Bernadete Sasso StuaniDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café, S/N, Subsetor Oeste, Ribeirão Preto, São Paulo, Brazil.
Maria Cristina BorsattoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida Do Café, S/N, Subsetor Oeste, Ribeirão Preto, São Paulo, Brazil.
Silmara Aparecida Milori CoronaDepartment of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Funding

conselho nacional de desenvolvimento científico e tecnológico Individual Scholarshipcoordenação de aperfeiçoamento de pessoal de nível superior Individual Scholarship
6 · The paper itself

Abstract

During orthodontic tooth movement (OTM), there is the release of cytokines in the gingival crevicular fluid (GCF) that are supposed to participate in the bone remodeling. This systematic review aimed at assessing the effects of photobiomodulation (PBM) on the levels of these cytokines during OTM. This systematic review according to Cochrane Collaboration guidelines aimed to answer the clinical question following the PICOS strategy. The broad search in the literature was performed before 05 April, 2021 in six electronic databases (Pubmed, Web of Science, Scopus, Embase, Cochrane, Biblioteca Virtual de Saúde) and supplemented by the grey literature. The risk of bias of randomized and non-randomized clinical trials was evaluated by two tools: RoB 2 and ROBINS-I. Mean and standard deviation of cytokine levels was extracted to meta-analysis, and the GRADE system was applied to assess the quality of the evidence. Nine studies were included in this review. Low-level laser therapy (LLLT) was the photobiomodulation type used in most of the studies (n = 8). The wavelengths used varied from 618 to 980 nm and also differed concerning the light emission pattern. LLLT increased the levels of IL-1β, IL-8, OPN, and PGE2, but not TNF-α1, TGF-β1. The levels of IL6, RANKL, and OPG presented conflicting results. LLLT was statistically associated with an increase of IL-1β levels (standard mean difference [SMD] = 1.99; 95% confidence interval = 0.66 to 3.33; p < 0.001) with low certainty of evidence. LLLT may increase the levels of IL-1β and other cytokines; however, the results should be interpreted with caution due to protocol variations between studies, and the few studies added in the meta-analysis.

Indexed as

CytokinesGingival Crevicular FluidImmunomodulationLow-Level Light TherapyTooth Movement TechniquesHumansCytokinesCytokinesInterleukin 1 betaLaser therapyLow-level laser therapyOrthodonticsOrthodontic tooth movement

Identifiers

PMID34599400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.