ArticleThe Plant cell2022
The calcium-dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- The E3 ubiquitin ligases ATL31/6 mediate TMK1 degradation to downregulate TMK1-dependent auxin signaling in Arabidopsis.Plant communications · 2026Article
- Interplay of different signaling mechanisms in regulating programmed cell death during plant development and in response to stresses.Protoplasma · 2026Review
- Membrane-associated DELLA degradation modulates growth under carbon/nitrogen imbalance.The Plant cell · 2026Article
- Calcium-Dependent Protein Kinases in Plants: Structure, Signaling, and Multifaceted Regulatory Roles in Development and Stress Adaptation.International journal of molecular sciences · 2026Review
- Ubiquitin-Mediated Proteolysis as a Regulator of the Plant Defense-Growth Balance.Plants (Basel, Switzerland) · 2026Review
- Molecular Mechanisms of Plant Stress Memory: Roles of Non-Coding RNAs and Alternative Splicing.Plants (Basel, Switzerland) · 2025Review
- E3-Ubiquitin Ligase SgATL31 Promotes Anthracnose Resistance in Stylosanthes by Modulating ROS Burst and Antioxidant Defence: A Proteomic and Functional Study.Molecular plant pathology · 2025Article
- The E3 ubiquitin ligase SlATL2 suppresses tomato immunity by promoting SlCSN5a degradation duringHorticulture research · 2025Article
- The E3 ubiquitin ligase TaGW2 facilitates TaSnRK1γ and TaVPS24 degradation to enhance stripe rust susceptibility in wheat.Plant biotechnology journal · 2025Article
- Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity.Journal of advanced research · 2025Article
- Phosphorylation of PIP2;7 by CPK28 or Phytophthora kinase effectors dampens pattern-triggered immunity in Arabidopsis.Plant communications · 2025Article
- Subfamily C7 Raf-like kinases MRK1, RAF26, and RAF39 regulate immune homeostasis and stomatal opening in Arabidopsis thaliana.The New phytologist · 2024Article
- The Multifaceted Ubiquitination of BIK1 During Plant Immunity inInternational journal of molecular sciences · 2024Review
- Proteolysis in plant immunity.The Plant cell · 2024Review
- A viral effector blocks the turnover of a plant NLR receptor to trigger a robust immune response.The EMBO journal · 2024Article
- Article
- The RING-Type E3 Ubiquitin Ligase GenePlants (Basel, Switzerland) · 2024Article
- A fungal core effector exploits the OsPUX8B.2-OsCDC48-6 module to suppress plant immunity.Nature communications · 2024Article
- Modulation of early gene expression responses to water deprivation stress by the E3 ubiquitin ligase ATL80: implications for retrograde signaling interplay.BMC plant biology · 2024Article
- The Auto-Regulation of ATL2 E3 Ubiquitin Ligase Plays an Important Role in the Immune Response againstInternational journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune responses are triggered when pattern recognition receptors recognize microbial molecular patterns. The Arabidopsis (Arabidopsis thaliana) receptor-like cytoplasmic kinase BOTRYTIS-INDUCED KINASE1 (BIK1) acts as a signaling hub of plant immunity. BIK1 homeostasis is maintained by a regulatory module in which CALCIUM-DEPENDENT PROTEIN KINASE28 (CPK28) regulates BIK1 turnover via the activities of two E3 ligases. Immune-induced alternative splicing of CPK28 attenuates CPK28 function. However, it remained unknown whether CPK28 is under proteasomal control. Here, we demonstrate that CPK28 undergoes ubiquitination and 26S proteasome-mediated degradation, which is enhanced by flagellin treatment. Two closely related ubiquitin ligases, ARABIDOPSIS TÓXICOS EN LEVADURA31 (ATL31) and ATL6, specifically interact with CPK28 at the plasma membrane; this association is enhanced by flagellin elicitation. ATL31/6 directly ubiquitinate CPK28, resulting in its proteasomal degradation. Furthermore, ATL31/6 promotes the stability of BIK1 by mediating CPK28 degradation. Consequently, ATL31/6 positively regulate BIK1-mediated immunity. Our findings reveal another mechanism for attenuating CPK28 function to maintain BIK1 homeostasis and enhance immune responses.
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