ReviewNature reviews. Rheumatology2021
Fatigue in inflammatory rheumatic diseases: current knowledge and areas for future research.
Review in Nature reviews. Rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Instruments for measuring fatigue in people with rheumatic and musculoskeletal diseases: a systematic review of measurement properties.RMD open · 2025Pooled it
- Pooled it
- Pooled it
- High-intensity exercise improves multidimensional fatigue and health-related quality of life in rheumatoid arthritis: a randomized controlled study.Arthritis research & therapy · 2025Trial
- Trial
- Short-Interval Discordance Between Fatigue and Joint Counts in Rheumatoid Arthritis.International journal of rheumatic diseases · 2026Article
- Diagnostic Anchoring on Positive Autoimmune Serologies in Polysymptomatic Patients.Journal of general internal medicine · 2026Article
- Fatigue beyond inflammation in inflammatory rheumatic diseases: a narrative review and treatable-traits framework.Rheumatology international · 2026Review
- Fatigue in Sjögren's Disease - Integrating Biomedical and Psychosocial Aspects: A Narrative Review.Rheumatology and therapy · 2026Review
- An intelligent electronic-textile system with adaptive sweat-regulation for continuous exercise-induced fatigue monitoring.Nature communications · 2026Article
- Fatigue in Middle-Aged and Older Adults with Axial Spondyloarthritis: A Sex-Stratified Case-Control Study.Journal of clinical medicine · 2026Article
- Fatigue in primary and associated Sjögren's disease: similar burden, distinct determinants.Clinical rheumatology · 2026Article
- Article
- Physical Activity for Human and Planetary Health: Incorporating Green Exercise in the Management of Rheumatic Disease.Rheumatic diseases clinics of North America · 2026Review
- A Cross-Sectional Study of the Relationship Between Disease Activity and Fatigue in Rheumatoid Arthritis Patients at King Abdulaziz University Hospital, Saudi Arabia.Open access rheumatology : research and reviews · 2026Article
- Exploring the feasibility of modeling next-day fatigue and sleepiness using digital sleep tracker data in neurodegenerative and immune-mediated inflammatory diseases.Frontiers in digital health · 2026Article
- Machine-learning approach to dissect the clinical heterogeneity of IBD-associated fatigue.BMJ digital health & AI · 2026Article
- Adapting to living with systemic autoimmune rheumatic diseases; a qualitative exploration of patient and clinician perspectives.Rheumatology international · 2025Article
- Mediators of the association between rheumatoid arthritis and depression.BMC public health · 2025Article
- Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases.Nature reviews. Neurology · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Fatigue is a complex phenomenon and an important health concern for many people with chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis, primary Sjögren syndrome and systemic lupus erythematosus. Although some clinical trials have shown the benefits of cognitive behavioural therapy in fatigue management, the effect of this approach is relatively modest, and no curative treatment has been identified. The pathogenesis of fatigue remains unclear. Despite many challenges and limitations, a growing body of research points to roles for the immune system, the central and autonomic nervous systems and the neuroendocrine system in the induction and maintenance of fatigue in chronic diseases. New insights indicate that sleep, genetic susceptibility, metabolic disturbances and other biological and physiological mechanisms contribute to fatigue. Furthermore, understanding of the relationships between psychosocial factors and fatigue is increasing. However, the interrelationships between these diverse mechanisms and fatigue remain poorly defined. In this Review, we outline various biological, physiological and psychosocial determinants of fatigue in inflammatory rheumatic diseases, and propose mechanistic and conceptual models of fatigue to summarize current understanding, stimulate debate and develop further research ideas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.