Evidence map›Paper›PMID 34599305›Full record

ArticleNature2021

Regulation of prefrontal patterning and connectivity by retinoic acid.

Mikihito Shibata, Kartik Pattabiraman, Belen Lorente-Galdos, David Andrijevic, Suel-Kee Kim, Navjot Kaur, Sydney K Muchnik, Xiaojun Xing, Gabriel Santpere, Andre M M Sousa and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 163 citations in OpenAlex.

  1. Article
  2. Article
  3. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
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  12. Convergent re-evolution of CNS structures: focus on the fovea.Current opinion in genetics & development · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Challenges of studying signaling metabolites in early development.Nature structural & molecular biology · 2026
    Article
  17. Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Mikihito Shibata *Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Kartik Pattabiraman *Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Belen Lorente-GaldosDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
David AndrijevicDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5703-3837
Suel-Kee KimDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0240-9304
Navjot KaurDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Sydney K MuchnikDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Xiaojun XingDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Gabriel SantpereDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Andre M M SousaDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1740-5066
Nenad SestanDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.ORCID http://orcid.org/0000-0003-0966-9619
Yale University · USYale Cancer Center · USUniversitat Pompeu Fabra · ESUniversity of Wisconsin–Madison · US

Funding

TRAINING PROGRAM IN CHILDHOOD NEUROPSYCHIATRIC DISORDERST32MH018268 · NIMH · YALE UNIVERSITY · PI Michael H Bloch, MICHAEL J CROWLEY · 1985 to 2026
$11.0M
Functional Genomics of Human Brain DevelopmentP50MH106934 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2014 to 2019
$7.9M
1/2 Cell Type and Region-Specific Regulatory Networks in Human Brain Development and DisordersU01MH116488 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2018 to 2022
$6.5M
Yale Macaque Brain ResourceR01MH113257 · NIMH · YALE UNIVERSITY · PI Alvaro Duque · 2017 to 2026
$4.3M
2/2 Somatic mosaicism and autism spectrum disorderU01MH106874 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2015 to 2019
$4.0M
1/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110926 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2016 to 2019
$3.2M
Identification of Genetic and Molecular Bases of Derived Phenotypes in Primate Brain DevelopmentR01HG010898 · NHGRI · YALE UNIVERSITY · PI SANTPERE BARO, GABRIEL, SESTAN, NENAD · 2020 to 2023
$2.2M
Medical Research Council MR/R006237/1NHGRI NIH HHS R01 HG010898NIH HHS HG010898NIH HHS MH106874NIH HHS MH106934NIH HHS MH110926NIH HHS T32 MH18268NIMH NIH HHS P50 MH106934NIMH NIH HHS R01 MH110926NIMH NIH HHS R01 MH113257NIMH NIH HHS T32 MH018268NIMH NIH HHS U01 MH106874NIMH NIH HHS U01 MH116488
6 · The paper itself

Abstract

The prefrontal cortex (PFC) and its connections with the mediodorsal thalamus are crucial for cognitive flexibility and working memory

Indexed as

OrganogenesisAnimalsAxonsCerebral CortexDown-RegulationFemaleHumansMacaca mulattaMaleMicePan troglodytesPrefrontal CortexReceptors, Retinoic AcidRetinoid X Receptor gammaSignal TransductionSynapsesReceptors, Retinoic Acidretinoic acid receptor betaRetinoid X Receptor gammaTretinoin

Identifiers

PMID34599305
PMCPMC9018119
OpenAlexW3203602359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.