Evidence map›Paper›PMID 34599210›Full record

ArticleScientific reports2021

In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets.

Céline Bourdon, Mekki Boussaha, Philippe Bardou, Marie-Pierre Sanchez, Sandrine Le Guillou, Thierry Tribout, Hélène Larroque, Didier Boichard, Rachel Rupp, Fabienne Le Provost and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Céline BourdonUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Mekki BoussahaUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Philippe BardouSigenae, INRAE, 31326, Castanet-Tolosan, France.ORCID 0000-0002-0004-0251
Marie-Pierre SanchezUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.ORCID 0000-0002-1371-5342
Sandrine Le GuillouUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.ORCID 0000-0002-0349-0047
Thierry TriboutUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Hélène LarroqueGenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.
Didier BoichardUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.ORCID 0000-0003-0361-2961
Rachel RuppGenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.ORCID 0000-0003-3375-5816
Fabienne Le Provost *Université Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Gwenola Tosser-Klopp *GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France. gwenola.tosser@inrae.fr.ORCID 0000-0003-0550-4673
AgroParisTech · FRÉcole Nationale Vétérinaire de Toulouse · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs are small noncoding RNAs that have important roles in the lactation process and milk biosynthesis. Some polymorphisms have been studied in various livestock species from the perspective of pathology or production traits. To target variants that could be the causal variants of dairy traits, genetic variants of microRNAs expressed in the mammary gland or present in milk and localized in dairy quantitative trait loci (QTLs) were investigated in bovine, caprine, and ovine species. In this study, a total of 59,124 (out of 28 millions), 13,427 (out of 87 millions), and 4761 (out of 38 millions) genetic variants in microRNAs expressed in the mammary gland or present in milk were identified in bovine, caprine, and ovine species, respectively. A total of 4679 of these detected bovine genetic variants are located in dairy QTLs. In caprine species, 127 genetic variants are localized in dairy QTLs. In ovine species, no genetic variant was identified in dairy QTLs. This study leads to the detection of microRNA genetic variants of interest in the context of dairy production, taking advantage of whole genome data to identify microRNA genetic variants expressed in the mammary gland and localized in dairy QTLs.

Indexed as

Genetic VariationGenomeGenomicsQuantitative Trait, HeritableQuantitative Trait LociAnimalsComputational BiologyGenome-Wide Association StudyMicroRNAsPolymorphism, Single NucleotideRuminantsSequence Analysis, DNAMicroRNAs

Identifiers

PMID34599210
PMCPMC8486775
OpenAlexW3201855687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.