ArticleNature communications2021
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70citing papers in PubMed
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70 citing papers in PubMed, 126 citations in OpenAlex.
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- A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Molecular heterogeneity and clonal origin of CCR8Nature communications · 2026Article
- Nrf2-mediated metabolic reprogramming drives regulatory T cell accumulation in hepatocellular carcinoma.Nature communications · 2026Article
- Prognostic significance and tumor cell interactions of tumor-associated neutrophils in gastric cancer.Molecular medicine (Cambridge, Mass.) · 2026Article
- FN1Oncogene · 2026Article
- The endosteal niche regulates breast cancer cell dormancy in bone: identification of new molecular determinants.Bone research · 2026Article
- Host Proteome Remodeling During Group A Streptococcus Skin Infection.Molecular & cellular proteomics : MCP · 2026Article
- Polymersomes preventing brain infiltration of CD177Nature communications · 2026Article
- Tumor microenvironment-induced epigenetic reprogramming of Tregs and its impact on immunotherapy.Frontiers in genetics · 2026Review
- Inhibiting OAS3 suppresses the development of clear cell renal cell carcinoma by reducing cell proliferation and altering the tumor immune microenvironment.American journal of translational research · 2026Article
- AK3 as a Hypoxia-Angiogenesis-Related Prognostic Biomarker and Therapeutic Target in Clear Cell Renal Cell Carcinoma.International journal of general medicine · 2026Article
- Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target.International journal of biological sciences · 2026Review
- Prognostic, molecular characterization, and immune infiltration analysis of NUDT16 in clear cell renal cell carcinoma.BMC cancer · 2025Article
- Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma.Discover oncology · 2025Article
- Single-cell transcriptomics identifies SOCS3+ exhausted T cells as a biomarker facilitating clear cell renal cell carcinoma progression.Clinical and experimental medicine · 2025Article
- Single-cell sequencing technology in renal cancer: insights into tumor biology and clinical application.Biomarker research · 2025Review
- [Effects of lunar soil simulant and Earth soil on lung injury in mice].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
35 authors at 7 institutions in 4 countries.
Myung-Chul Kim *Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Nicholas Borcherding *Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA.
Kawther K Ahmed *Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0002-8526-0447
Andrew P Voigt *Medical Scientist Training Program, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0001-8107-8317
Ajaykumar VishwakarmaCancer Biology Graduate Program, University of Iowa, Iowa City, IA, 52242, USA.
Ryan KolbDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Paige N KluzDepartment of Pathology, University of Iowa, Iowa City, IA, 52242, USA.
Gaurav PandeyDepartment of Pathology, University of Iowa, Iowa City, IA, 52242, USA.
Umasankar DeDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.
Theodore DrashanskyDepartment of Anatomy and Cell Biology, University of Florida College of Medicine, 32610, Gainesville, FL, 32610, USA.ORCID 0000-0001-6215-1232
Eric Y HelmDepartment of Anatomy and Cell Biology, University of Florida College of Medicine, 32610, Gainesville, FL, 32610, USA.
Xin ZhangUF Health Cancer Center, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0001-9751-7054
Katherine N Gibson-CorleyDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2130, USA.
Julia Klesney-TaitDepartment of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Yuwen ZhuDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.ORCID 0000-0003-1434-6590
Jinglu LuDepartment of Breast Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, 200127, China.ORCID 0000-0001-5606-575X
Jinsong LuShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Xian HuangShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hongrui XiangShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jinke ChengShanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.ORCID 0000-0002-4344-5363
Dongyang WangDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Zheng WangDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Jian TangDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Jiajia HuDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Zhengting WangDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hua LiuDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Mingjia LiDepartment of Medicine, Division of Rheumatology & Clinical Immunology, University of Florida, 1600 Archer Road, Gainesville, FL, 32610-0275, USA.
Haoyang ZhuangDepartment of Medicine, Division of Rheumatology & Clinical Immunology, University of Florida, 1600 Archer Road, Gainesville, FL, 32610-0275, USA.
Dorina AvramUF Health Cancer Center, University of Florida, Gainesville, FL, 32610, USA.
Daohong ZhouUF Health Cancer Center, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0002-2400-6461
Rhonda BacherDepartment of Biostatistics, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0001-5787-476X
Song Guo ZhengDepartment of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Xuefeng WuDepartment of Breast Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, 200127, China. xuefengwu@shsmu.edu.cn.ORCID 0000-0002-6933-7280
Yousef ZakhariaDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2130, USA. yousef-zakharia@uiowa.edu.ORCID 0000-0001-9480-2626
Weizhou ZhangDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA. zhangw@ufl.edu.ORCID 0000-0002-8236-0346
Shanghai Jiao Tong University · CNUniversity of Iowa · USUniversity of Florida Health · USUniversity of Florida · USVanderbilt University Medical Center · USThe Ohio State University Wexner Medical Center · USUniversity of Colorado Anschutz Medical Campus · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MMedical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4MRole of Bcl11b in CD4+ T cells and innate lymphoid cellsR01AI067846 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA · 2007 to 2023
$6.2MProteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasisR01CA260239 · NCI · UNIVERSITY OF FLORIDA · PI ZHANG, WEIZHOU · 2021 to 2025
$2.5MObesity, inflammation and breast cancerR01CA200673 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7MCD177 suppresses breast-cancer development by inhibiting beta-cateninR01CA203834 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7MNCI NIH HHS P30 CA086862NCI NIH HHS R01 CA200673NCI NIH HHS R01 CA203834NCI NIH HHS R01 CA260239NIAID NIH HHS R01 AI067846NIEHS NIH HHS P30 ES005605NIGMS NIH HHS T32 GM007337NIGMS NIH HHS T32 GM139776
Abstract
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, using single-cell RNA sequencing of immune cells from renal clear cell carcinoma (ccRCC) patients, we identify two distinct transcriptional fates for TI Treg cells, Fate-1 and Fate-2. The Fate-1 signature is associated with a poorer prognosis in ccRCC and several other solid cancers. CD177, a cell surface protein normally expressed on neutrophil, is specifically expressed on Fate-1 TI Treg cells in several solid cancer types, but not on other TI or peripheral Treg cells. Mechanistically, blocking CD177 reduces the suppressive activity of Treg cells in vitro, while Treg-specific deletion of Cd177 leads to decreased tumor growth and reduced TI Treg frequency in mice. Our results thus uncover a functional CD177
Indexed as
HomeostasisAnimalsBase SequenceCarcinogenesisCarcinoma, Renal CellGene Expression ProfilingGene Expression Regulation, NeoplasticGPI-Linked ProteinsHumansIsoantigensKidney NeoplasmsLymphocytes, Tumor-InfiltratingMiceMice, KnockoutPrognosisReceptors, Cell SurfaceCD177 protein, humanCd177 protein, mouseGPI-Linked ProteinsIsoantigensReceptors, Cell Surface
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