ArticleNature communications2021
Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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54citing papers in PubMed, 1 pooled it
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Vaccines for COVID-19: A Systematic Review of Immunogenicity, Current Development, and Future Prospects.Frontiers in immunology · 2022Pooled it
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- Tracking down the origin and subsequent spread of SARS-CoV-2 lineage B.1.619.Virus evolution · 2025Article
- Integrating dynamical modeling and phylogeographic inference to characterize global influenza circulation.PNAS nexus · 2025Article
- Design, synthesis, and biological activity evaluation of dihydromyricetin derivatives against SARS-CoV-2-Omicron virus.Journal of enzyme inhibition and medicinal chemistry · 2024Article
- Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature.BMC infectious diseases · 2024Article
- Establishment of human post-vaccination SARS-CoV-2 standard reference sera.Journal of immunological methods · 2024Article
- Integrating dynamical modeling and phylogeographic inference to characterize global influenza circulation.medRxiv : the preprint server for health sciences · 2024Article
- Potential immune evasion of the severe acute respiratory syndrome coronavirus 2 Omicron variants.Frontiers in immunology · 2024Review
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- A cross-sectional study on health behavior changes during COVID-19 among adults in Malaysia.Frontiers in public health · 2024Article
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- Targeting Viral ORF3a Protein: A New Approach to Mitigate COVID-19 Induced Immune Cell Apoptosis and Associated Respiratory Complications.Advanced pharmaceutical bulletin · 2023Review
- Variant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City - from Alpha to Omicron.PLoS pathogens · 2023Article
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions.Human gene (Amsterdam, Netherlands) · 2023Article
- Five successive waves of SARS-CoV-2 infection in the Central African Republic: a prospective observational study from 2020-2022.The Pan African medical journal · 2023Observational
- Optimizing ancestral trait reconstruction of large HIV Subtype C datasets through multiple-trait subsampling.Virus evolution · 2023Article
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- On the Evolutionary Trajectory of SARS-CoV-2: Host Immunity as a Driver of Adaptation in RNA Viruses.Viruses · 2022Review
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Authors and funding
70 authors at 20 institutions in 15 countries.
Gytis Dudas *Gothenburg Global Biodiversity Centre, Gothenburg, Sweden. gytisdudas@gmail.com.ORCID 0000-0002-0227-4158
Samuel L HongDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.ORCID 0000-0001-6354-4943
Barney I PotterDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Sébastien Calvignac-SpencerEpidemiology of Highly Pathogenic Organisms, Robert Koch Institute, 13353, Berlin, Germany.ORCID 0000-0003-4834-0509
Frédéric S Niatou-SingaWWF Central African Republic Programme Office, Dzanga Sangha Protected Areas, BP 1053, Bangui, Central African Republic.
Thais B TombolomakoWWF Central African Republic Programme Office, Dzanga Sangha Protected Areas, BP 1053, Bangui, Central African Republic.
Terence Fuh-NebaWWF Central African Republic Programme Office, Dzanga Sangha Protected Areas, BP 1053, Bangui, Central African Republic.
Ulrich VickosInfectious and Tropical Diseases Unit, Department of medicine, Amitié Hospital, Bangui, Central African Republic.
Markus UlrichEpidemiology of Highly Pathogenic Organisms, Robert Koch Institute, 13353, Berlin, Germany.
Fabian H LeendertzEpidemiology of Highly Pathogenic Organisms, Robert Koch Institute, 13353, Berlin, Germany.ORCID 0000-0002-2169-7375
Kamran KhanBlueDot, Toronto, ON, M5J 1A7, Canada.
Carmen HuberBlueDot, Toronto, ON, M5J 1A7, Canada.ORCID 0000-0002-3744-4663
Alexander WattsBlueDot, Toronto, ON, M5J 1A7, Canada.
Ingrida OlendraitėHematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Joost SnijderBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
Kim N WijnantBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
Alexandre M J J BonvinBijvoet Centre for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.ORCID 0000-0001-7369-1322
Pascale MartresMicrobiology, Centre Hospitalier René Dubos, Cergy Pontoise, France.
Sylvie BehillilMolecular Genetics of RNA viruses, CNRS UMR 3569, Université de Paris, Institut Pasteur, Paris, France.
Ahidjo AyoubaTransVIHMI, Université de Montpellier, IRD, INSERM, 911 Avenue Agropolis, 34394, Montpellier cedex, France.
Martin Foudi MaidadiCentre de Recherches sur les Maladies Émergentes, Ré-émergentes et la Médecine Nucléaire, Institut de Recherches Médicales et D'études des Plantes Médicinales, Yaoundé, Cameroon.ORCID 0000-0002-6679-1111
Dowbiss Meta DjomsiCentre de Recherches sur les Maladies Émergentes, Ré-émergentes et la Médecine Nucléaire, Institut de Recherches Médicales et D'études des Plantes Médicinales, Yaoundé, Cameroon.
Celestin GodweCentre de Recherches sur les Maladies Émergentes, Ré-émergentes et la Médecine Nucléaire, Institut de Recherches Médicales et D'études des Plantes Médicinales, Yaoundé, Cameroon.
Christelle ButelTransVIHMI, Université de Montpellier, IRD, INSERM, 911 Avenue Agropolis, 34394, Montpellier cedex, France.
Aistis ŠimaitisThe Office of the Government of the Republic of Lithuania, Vilnius, Lithuania.
Miglė GabrielaitėCenter for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-7959-8767
Monika KatėnaitėHematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Rimvydas NorvilasHematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Ligita RaugaitėHematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Giscard Wilfried KoyawedaLe Laboratoire National de Biologie Clinique et de Santé Publique (LNBCSP), Bangui, Central African Republic.
Jephté Kaleb KandouLe Laboratoire National de Biologie Clinique et de Santé Publique (LNBCSP), Bangui, Central African Republic.
Rimvydas JonikasDepartment of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
Inga NasvytienėDepartment of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
Živilė ŽemeckienėDepartment of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
Dovydas GečysInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Kamilė TamušauskaitėInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID 0000-0003-1649-3439
Milda NorkienėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0000-0003-1679-2404
Emilija VasiliūnaitėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0000-0003-4084-1544
Danguolė ŽiogienėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Albertas TiminskasInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Marius ŠukysDepartment of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.ORCID 0000-0002-2432-0223
Mantas ŠarauskasDepartment of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
Gediminas AlzbutasInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Adrienne Amuri AzizaNational Institute for Biomedical Research (INRB), Avenue De la Democratie (Ex Huileries), BP 1197, Kinshasa-Gombe, Democratic Republic of the Congo.ORCID 0000-0002-5516-0779
Eddy Kinganda LusamakiNational Institute for Biomedical Research (INRB), Avenue De la Democratie (Ex Huileries), BP 1197, Kinshasa-Gombe, Democratic Republic of the Congo.
Jean-Claude Makangara CigoloNational Institute for Biomedical Research (INRB), Avenue De la Democratie (Ex Huileries), BP 1197, Kinshasa-Gombe, Democratic Republic of the Congo.ORCID 0000-0002-1791-2247
Francisca Muyembe MaweteNational Institute for Biomedical Research (INRB), Avenue De la Democratie (Ex Huileries), BP 1197, Kinshasa-Gombe, Democratic Republic of the Congo.
Emmanuel Lokilo LofikoNational Institute for Biomedical Research (INRB), Avenue De la Democratie (Ex Huileries), BP 1197, Kinshasa-Gombe, Democratic Republic of the Congo.
Placide Mbala KingebeniNational Institute for Biomedical Research (INRB), Avenue De la Democratie (Ex Huileries), BP 1197, Kinshasa-Gombe, Democratic Republic of the Congo.
Jean-Jacques Muyembe TamfumNational Institute for Biomedical Research (INRB), Avenue De la Democratie (Ex Huileries), BP 1197, Kinshasa-Gombe, Democratic Republic of the Congo.
Marie Roseline Darnycka BelizaireWorld Health Organization, Central African Republic Office, Bangui, Central African Republic.
René Ghislain EssombaNational Public Health Laboratory, Ministry of Public Health, Yaoundé, Cameroon.
Marie Claire Okomo AssoumouNational Public Health Laboratory, Ministry of Public Health, Yaoundé, Cameroon.
Akenji Blaise MboringongNational Public Health Laboratory, Ministry of Public Health, Yaoundé, Cameroon.
Alle Baba DiengWorld Health Organization, Cameroon Office, Yaoundé, Cameroon.
Dovilė JuozapaitėHematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.ORCID 0000-0001-7240-4301
Salome HoschSwiss Tropical and Public Health Institute, Basel, Switzerland.ORCID 0000-0001-9290-3589
Justino ObamaMinistry of Health and Social Welfare, Malabo, Equatorial Guinea.
Mitoha Ondo'o AyekabaMinistry of Health and Social Welfare, Malabo, Equatorial Guinea.
Daniel NaumovasHematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.ORCID 0000-0002-5968-4182
Arnoldas PautieniusInstitute of Microbiology and Virology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Clotaire Donatien RafaïLe Laboratoire National de Biologie Clinique et de Santé Publique (LNBCSP), Bangui, Central African Republic.
Astra VitkauskienėDepartment of Laboratory Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Rasa UgenskienėDepartment of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
Alma GedvilaitėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0000-0003-4779-0559
Darius ČereškevičiusDepartment of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
Vaiva LesauskaitėInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lukas ŽemaitisInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Laimonas GriškevičiusHematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Guy Baele *Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium. guy.baele@kuleuven.be.ORCID 0000-0002-1915-7732
Vilnius University · LTLithuanian University of Health Sciences · LTUniversity of Bangui · CFUniversity of Kinshasa · CDHospital of Lithuanian University of Health Sciences Kaunas Clinics · LTInstitut de Recherches Médicales et d’Etudes des Plantes Médicinales · CMRega Institute for Medical Research · BERobert Koch Institute · DEUtrecht University · NLBlueDot (Canada) · CAInserm · FRNational University of Equatorial Guinea · GQUniversité de Yaoundé I · CMCentre Hospitalier René-Dubos · FRCentre National de la Recherche Scientifique · FRMinistry of Public Health · CMNational Institute of Biomedical Research · CDRigshospitalet · DKSt. Michael's Hospital · CASwiss Tropical and Public Health Institute · CH
Funding
World Health Organization 001
Abstract
Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers.
Indexed as
Africa, CentralAntibodies, NeutralizingCOVID-19EuropeHumansImmune EvasionMutationPhylogenyPhylogeographySARS-CoV-2Spike Glycoprotein, CoronavirusTravelAntibodies, NeutralizingSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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