Evidence map›Paper›PMID 34599162›Full record

ArticleNature communications2021

Geographical drivers and climate-linked dynamics of Lassa fever in Nigeria.

David W Redding, Rory Gibb, Chioma C Dan-Nwafor, Elsie A Ilori, Rimamdeyati Usman Yashe, Saliu H Oladele, Michael O Amedu, Akanimo Iniobong, Lauren A Attfield, Christl A Donnelly and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Climate-driven host ecology as a framework for zoonotic disease risk: Understanding transferability across arenavirus systems.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  16. Climate sensitivity is widely but unevenly spread across zoonotic diseases.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

David W Redding *Institute of Zoology, Zoological Society of London, Regent's Park, London, NW1 4RY, United Kingdom. dwredding@gmail.com.ORCID http://orcid.org/0000-0001-8615-1798
Rory Gibb *Centre for Biodiversity and Environment Research, Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, United Kingdom.ORCID http://orcid.org/0000-0002-0965-1649
Chioma C Dan-NwaforNigeria Centre for Disease Control, Abuja, Nigeria.ORCID http://orcid.org/0000-0002-3294-2276
Elsie A IloriNigeria Centre for Disease Control, Abuja, Nigeria.
Rimamdeyati Usman YasheNigeria Centre for Disease Control, Abuja, Nigeria.
Saliu H OladeleNigeria Centre for Disease Control, Abuja, Nigeria.
Michael O AmeduNigeria Centre for Disease Control, Abuja, Nigeria.
Akanimo IniobongNigeria Centre for Disease Control, Abuja, Nigeria.
Lauren A AttfieldInstitute of Zoology, Zoological Society of London, Regent's Park, London, NW1 4RY, United Kingdom.
Christl A DonnellyMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, W2 1PG, London, United Kingdom.ORCID http://orcid.org/0000-0002-0195-2463
Ibrahim AbubakarInstitute of Global Health, University College London, Gower Street, London, WC1E 6BT, United Kingdom.ORCID http://orcid.org/0000-0002-0370-1430
Kate E JonesInstitute of Zoology, Zoological Society of London, Regent's Park, London, NW1 4RY, United Kingdom.ORCID http://orcid.org/0000-0001-5231-3293
Chikwe IhekweazuNigeria Centre for Disease Control, Abuja, Nigeria.

Funding

Medical Research Council MR/R015600/1Medical Research Council MR/R02491X/1Wellcome TrustWellcome Trust 220179/Z/20/ZWorld Health Organization 001
6 · The paper itself

Abstract

Lassa fever is a longstanding public health concern in West Africa. Recent molecular studies have confirmed the fundamental role of the rodent host (Mastomys natalensis) in driving human infections, but control and prevention efforts remain hampered by a limited baseline understanding of the disease's true incidence, geographical distribution and underlying drivers. Here, we show that Lassa fever occurrence and incidence is influenced by climate, poverty, agriculture and urbanisation factors. However, heterogeneous reporting processes and diagnostic laboratory access also appear to be important drivers of the patchy distribution of observed disease incidence. Using spatiotemporal predictive models we show that including climatic variability added retrospective predictive value over a baseline model (11% decrease in out-of-sample predictive error). However, predictions for 2020 show that a climate-driven model performs similarly overall to the baseline model. Overall, with ongoing improvements in surveillance there may be potential for forecasting Lassa fever incidence to inform health planning.

Indexed as

Epidemiological MonitoringAnimalsClimateDisease ReservoirsGeographyHumansIncidenceLassa FeverLassa virusMurinaeNigeriaPovertyRetrospective StudiesSpatio-Temporal AnalysisUrbanization

Identifiers

PMID34599162
PMCPMC8486829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.