ArticleBMJ open diabetes research & care2021
Complexity of antidiabetic medication regimen is associated with increased diabetes-related distress in persons with type 2 diabetes mellitus.
Article in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Comparing the Effects of Diabetes-Specific and Overall Medication Regimen Complexity on Diabetes Distress.The science of diabetes self-management and care · 2026Trial
- Diabetes Medication Regimen Complexity and Glycemic Outcomes among Medically Underserved Latino Adults: Implications for Pharmacoequity.Journal of immigrant and minority health · 2026Article
- Prevalence and determinants of diabetes-related psychological distress in a tertiary care setting in Tamil Nadu, India: cross-sectional study.BJPsych open · 2026Article
- Associations between impaired awareness of hypoglycaemia and mental health in insulin-treated type 2 and type 1 diabetes in the Hypo-METRICS study.Diabetic medicine : a journal of the British Diabetic Association · 2026Observational
- Interaction of self-efficacy and sense of personal control on diabetes distress in older adults with type 2 diabetes: a cross-sectional study.Frontiers in public health · 2026Article
- The association between poor glycemic control and PTSD in patients with diabetes mellitus in primary healthcare in Palestine.Frontiers in medicine · 2026Article
- Article
- Development of a culturally tailored medical nutrition therapy to improve dietary adherence in type 2 diabetes in Benin: an ORBIT model-based protocol.Frontiers in nutrition · 2026Article
- Impact of Virtual Clinics on Diabetes Distress and HbA1c Levels Among Patients with Diabetes Mellitus in Saudi Arabia.Medicina (Kaunas, Lithuania) · 2025Article
- The role of medication regimen complexity in diabetes management: a rapid review.Therapeutic advances in endocrinology and metabolism · 2025Review
- Psychological distress and its impact on glycemic control in patients with diabetes, Northwest Ethiopia.Frontiers in medicine · 2025Article
- Associations between Diabetes-Specific Medication Regimen Complexity and Cardiometabolic Outcomes among Underserved Non-Hispanic Black Adults Living with Type 2 Diabetes Mellitus.Pharmacy (Basel, Switzerland) · 2024Article
- Chinese Healthy Eating Index (CHEI) and risk of diabetes in Chinese adults: a prospective cohort study.European journal of nutrition · 2024Article
- Association between diabetes distress and sociodemographic and/or socioeconomic factors among adults: A cross-sectional study.Heliyon · 2023Article
- The factors associated with orthorexia nervosa in type 2 diabetes and their effect on diabetes self-management scores.Eating and weight disorders : EWD · 2023Article
- Effect of Rifampicin on the Pharmacokinetics of Evogliptin in Healthy Volunteers.Drug design, development and therapy · 2022Article
- Predictors of medication regimen complexity and its impact on hemoglobin a1c in type 2 diabetes patients: a retrospective analysis in ambulatory care in Makkah City.Annals of Saudi medicineArticle
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5 authors.
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Abstract
introductionDiabetes-related distress is present in a high proportion of people with type 2 diabetes mellitus. We hypothesized that complexity of the antidiabetic medication regimen is a factor that is associated with diabetes-related distress. RESEARCH DESIGN AND
methodsThis was a retrospective study including a group of 74 patients managed at a tertiary care center. Patients with type 1 diabetes mellitus, steroid-induced diabetes, post-transplant diabetes, and other types of diabetes were excluded. Patients were screened using the Diabetes Distress Scale-2 (DDS-2). A Diabetes Medication Complexity Scoring (DMCS) system was developed to objectively assess the diabetes medication complexity. Based on DMCS, participants were categorized into three groups: low (n=26), moderate (n=22), and high (n=26) medication complexity.
resultsComplexity groups were similar in sociodemographic characteristics, diabetes duration, body mass index, and blood pressure as well as the prevalence of hypertension, hyperlipidemia and hypoglycemic episodes. However, there were significant differences for HbA1c with higher HbA1c in the high and moderate complexity groups than in the low group (p=0.006). The microvascular complications were also more common in higher complexity groups (p=0.003). The prevalence of diabetes-related distress (DDS-2 ≥6) was 34.6% in the low, 36.4% in the moderate and 69.2% in the high complexity groups (p=0.021). There were significant differences in DDS-2 score among complexity groups (p=0.009), with higher DDS-2 score in the high complexity group compared with the moderate (p=0.008) and low complexity groups (p=0.009). The difference in DDS-2 score remained significant after adjusting for HbA1c (p=0.024) but did not reach statistical significance after controlling for both HbA1c and microvascular complications (p=0.163).
conclusionsA complex antidiabetic medication regimen may be associated with high levels of diabetes-related distress.
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