Evidence map›Paper›PMID 34598831›Full record

ArticleNeurobiology of aging2021

Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus.

Carlene A Chinn, Honglei Ren, Julien L P Morival, Qing Nie, Marcelo A Wood, Timothy L Downing

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carlene A ChinnDepartment of Neurobiology and Behavior, School of Biological Sciences, University of California Irvine, Irvine, California; Center for the Neurobiology of Learning and Memory, University of California Irvine. Irvine, California.
Honglei RenNSF-Simons Center for Multiscale Cell Fate, University of California Irvine, Irvine, California; Center for Complex Biological Systems, University of California Irvine, Irvine, California.
Julien L P MorivalNSF-Simons Center for Multiscale Cell Fate, University of California Irvine, Irvine, California; Department of Biomedical Engineering, University of California Irvine, Irvine, California; UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California Irvine, Irvine, California.
Qing NieNSF-Simons Center for Multiscale Cell Fate, University of California Irvine, Irvine, California; Center for Complex Biological Systems, University of California Irvine, Irvine, California; Department of Mathematics, University of California Irvine, Irvine, California; Department of Developmental and Cell Biology, University of California Irvine, Irvine, California.
Marcelo A WoodDepartment of Neurobiology and Behavior, School of Biological Sciences, University of California Irvine, Irvine, California; Center for the Neurobiology of Learning and Memory, University of California Irvine. Irvine, California.
Timothy L DowningNSF-Simons Center for Multiscale Cell Fate, University of California Irvine, Irvine, California; Center for Complex Biological Systems, University of California Irvine, Irvine, California; Department of Biomedical Engineering, University of California Irvine, Irvine, California; UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California Irvine, Irvine, California. Electronic address: tim.downing@uci.edu.
University of California, Irvine · US

Funding

MINORITY BIOMEDICAL RESEARCHERS PROGRAMR25GM055246 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOTA-BRAVO, LUIS M · 1996 to 2022
$15.3M
Epigenetic suppression of histone methylation reverses age and AD-related cognitive declineRF1AG057558 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2018 to 2018
$3.8M
Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognitionR01AG051807 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI COTMAN, CARL WAYNE, WOOD, MARCELO ANDRES · 2016 to 2020
$3.1M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
Identifying a physiological basis for accelerated memory and synaptic plasticity vulnerability in females with AD pathologyR21AG067613 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI OBENAUS, ANDRE, WOOD, MARCELO ANDRES · 2020 to 2020
$432k
Development of an epigenetic clock that predicts age-impaired or age-unimpaired cognitive performanceR21AG078978 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI DOWNING, TIMOTHY LAMONT, WOOD, MARCELO ANDRES · 2022 to 2022
$395k
NIA NIH HHS R01 AG051807NIA NIH HHS R21 AG067613NIA NIH HHS R21 AG078978NIA NIH HHS RF1 AG057558NIGMS NIH HHS R25 GM055246NIMH NIH HHS T32 MH119049
6 · The paper itself

Abstract

DNA methylation is a well-characterized epigenetic modification involved in numerous molecular and cellular functions. Methylation patterns have also been associated with aging mechanisms. However, how DNA methylation patterns change within key brain regions involved in memory formation in an age- and sex-specific manner remains unclear. Here, we performed reduced representation bisulfite sequencing (RRBS) from mouse dorsal hippocampus - which is necessary for the formation and consolidation of specific types of memories - in young and aging mice of both sexes. Overall, our findings demonstrate that methylation levels within the dorsal hippocampus are divergent between sexes during aging in genomic features correlating to mRNA functionality, transcription factor binding sites, and gene regulatory elements. These results define age-related changes in the methylome across genomic features and build a foundation for investigating potential target genes regulated by DNA methylation in an age- and sex-specific manner.

Indexed as

Gene ExpressionAgingAnimalsDNA MethylationFemaleGene Expression Regulation, DevelopmentalHippocampusMaleMiceMice, Inbred C57BLOrgan SpecificitySex CharacteristicsAgingDNA methylationDorsal hippocampusLifespanTissue-specific

Identifiers

PMID34598831
PMCPMC9186538
OpenAlexW3195171525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.