Evidence map›Paper›PMID 34598811›Full record

ArticleTransplantation proceedings2021

COVID-19 and Heart Transplantation. Initial Experience in a Tertiary Hospital.

Raquel López-Vilella, Ignacio Sánchez-Lázaro, Víctor Donoso Trenado, Silvia Lozano Edo, Luis Martínez Dolz, Luis Almenar Bonet

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation proceedings, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Raquel López-VilellaHeart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain. Electronic address: lopez_raqvil@gva.es.
Ignacio Sánchez-LázaroHeart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.
Víctor Donoso TrenadoHeart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Silvia Lozano EdoDepartment of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain.
Luis Martínez DolzDepartment of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.
Luis Almenar BonetHeart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain; Universidad de Valencia, Valencia, Spain.
Hospital Universitari i Politècnic La Fe · ESInstituto de Salud Carlos III · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) is a viral infectious disease caused by the severe acute respiratory syndrome coronavirus 2 virus that is affecting the entire world population. The objective of this study was to analyze the repercussion of the disease in a group of patients at risk such as heart transplant recipients.

methodsFrom February 2020 to February 2021, heart transplant recipients diagnosed with COVID-19 were consecutively included. The total number of transplant recipients in outpatient follow-up at that time was 381. Three levels of infection were determined: group A: asymptomatic patients or with trivial symptoms without the need for hospital admission (6 patients); group B: patients admitted to the hospital for respiratory symptoms (12 patients); and group C: patients with severe symptoms and need for admission to the critical care unit (2 patients). At each risk level, medical performance was different: group A: close control, no therapeutic modification; group B: reduction of calcineurin inhibitor and substitution of mycophenolate mofetil for everolimus; group C: reduction of calcineurin inhibitor and withdrawal of mycophenolate mofetil.

resultsThe prevalence of infection in the series was 5.2%. Most patients admitted had a pathologic chest x-ray with fever, cough, dyspnea, or vomiting. The change in immunosuppression performed in patients in group 2 was well tolerated and there was no graft rejection. Antiviral treatment was little used. However, boluses of steroids and some antibiotics were used frequently. The need for supplemental oxygen was 50% in group 2 and 100% in group 3.

conclusionsA significant number of transplant recipients will be affected by COVID-19 (5.3%). Management of the infection will depend on the severity of the infection and must be based on a balance between reduction and adjustment of immunosuppression, strict control of the cardiologic situation, and treatment of the infection.

Indexed as

COVID-19Heart TransplantationKidney TransplantationHumansImmunosuppressive AgentsSARS-CoV-2Tertiary Care CentersTransplant RecipientsImmunosuppressive Agents

Identifiers

PMID34598811
PMCPMC8418905
OpenAlexW3197225910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.