Evidence map›Paper›PMID 34598711›Full record

ArticleHereditas2021

Comprehensive characterization and clinical relevance of the SWI/SNF copy number aberrations across human cancers.

Zhiwei Xing, Buhuan Ma, Weiting Sun, Yimin Sun, Caixia Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zhiwei XingThe Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Buhuan MaInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Weiting SunInner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Yimin SunNational Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China.
Caixia LiuThe Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China. lcxzhg1974@163.com.
Inner Mongolia Medical University · CNTsinghua University · CN

Funding

Inner Mongolia Medical University "Science and Technology Million Project" [YKD2018KJBW(LH)013]Inner Mongolia science and technology planning project No. 2020GG0171
6 · The paper itself

Abstract

backgroundAlterations in genes encoding chromatin regulatory proteins are prevalent in cancers and may confer oncogenic properties and molecular changes linked to therapy resistance. However, the impact of copy number alterations (CNAs) of the SWItch/Sucrose NonFermentable (SWI/SNF) complex on the oncogenic and immunologic properties has not been systematically explored across human cancer types.

methodsWe comprehensively analyzed the genomic, transcriptomic and clinical data of The Cancer Genome Atlas (TCGA) dataset across 33 solid cancers.

resultsCNAs of the SWI/SNF components were identified in more than 25% of all queried cancers, and tumors harboring SWI/SNF CNAs demonstrated a worse overall survival (OS) than others in several cancer types. Mechanistically, the SCNA events in the SWI/SNF complex are correlated with dysregulated genomic features and oncogenic pathways, including the cell cycle, DNA damage and repair. Notably, the SWI/SNF CNAs were associated with homologous recombination deficiency (HRD) and improved clinical outcomes of platinum-treated ovarian cancer. Furthermore, we observed distinct immune infiltrating patterns and immunophenotypes associated with SWI/SNF CNAs in different cancer types.

conclusionThe CNA events of the SWI/SNF components are a key process linked to oncogenesis, immune infiltration and therapeutic responsiveness across human cancers.

Indexed as

DNA Copy Number VariationsNeoplasmsChromosomal Proteins, Non-HistoneDNA-Binding ProteinsHumansSucroseChromosomal Proteins, Non-HistoneDNA-Binding ProteinsSucroseCopy number alterationGenome instabilityImmune cell infiltrationSWI/SNF complex

Identifiers

PMID34598711
PMCPMC8487138
OpenAlexW3203083351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.