ArticleBMC immunology2021
Highly individual- and tissue-specific expression of glycoprotein group A and B blood antigens in the human kidney and liver.
Article in BMC immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- B3GALT5 regulates renal A/B antigen levels: a determinant of prognosis and rejection in ABO-incompatible kidney transplantation.Journal of global health · 2026Article
- Relationship Between ABO/Rh Blood Groups and Knee Osteoarthritis: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Western Blot Detection of Blood Group A and B Antigens.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis.Frontiers in immunology · 2024Article
- Lewis x-carrying O-glycans are candidate modulators for conceptus attachment in pigs†.Biology of reproduction · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundCurrently, research on the quantitative distribution of ABO antigens in different organs and tissues remains limited. We aimed to examine the individual characteristics of blood group glycoprotein A and B antigen expression in human kidneys and livers.
methodsWe obtained human samples, including the renal artery, renal vein, renal tissue, hepatic artery, hepatic vein, portal vein, and hepatic tissue, from 24 deceased organ transplant donors. The expression of the blood group antigens glycoprotein A and B was analysed and compared by Western blotting.
resultsThere was no significant difference in the expression between blood group glycoprotein A and B antigens at any of the seven sites (p > 0.05). The expression of both A and B antigens was highest in renal tissue and the portal vein and was lowest in the renal artery. A large difference in glycoprotein antigen expression was observed among various donors or different regions of the same individual. Univariate analysis revealed that glycoprotein A/B antigens were affected by the age and sex of donors and were significantly higher in males and in young people.
conclusionsOur study found that blood group glycoprotein antigen expression showed certain trends and distinct distribution in the kidney, liver, and vessels among individuals and in different regions of the same individual, which may explain the different clinical outcomes of patients who received ABO-incompatible transplantation.
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