Evidence map›Paper›PMID 34598082›Full record

ArticleComputer methods and programs in biomedicine2021

Ocular biomechanics due to ground blast reinforcement.

Alireza Karimi, Reza Razaghi, Christopher A Girkin, J Crawford Downs

Abstract read
In one paragraph

Article in Computer methods and programs in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  3. Article
  4. Contact lens fitting and changes in the tear film dynamics: mathematical and computational models review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Review
  5. Blast injury: Impact to the cornea.Experimental eye research · 2024
    Review
  6. Article
  7. Biomechanics of open-globe injury: a review.Biomedical engineering online · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alireza KarimiDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, 1670 University Boulevard, VH 390A, Birmingham, AL 35294, United States. Electronic address: akarimi@uabmc.edu.
Reza RazaghiResearch Department, Heel of Scene Ltd., 2 Chome-12-3 Honmachi, Shibuya City, Tokyo, Japan. Electronic address: razaghireza@outlook.com.
Christopher A GirkinDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, 1670 University Boulevard, VH 390A, Birmingham, AL 35294, United States. Electronic address: cgirkin@uabmc.edu.
J Crawford DownsDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, 1670 University Boulevard, VH 390A, Birmingham, AL 35294, United States. Electronic address: cdowns@uabmc.edu.

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
Age-related changes in optic nerve head structure and biomechanicsR01EY018926 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOWNS, J CRAWFORD, GIRKIN, CHRISTOPHER ANTHONY · 2008 to 2015
$2.6M
Optic Nerve Head Mechanobiology in GlaucomaR01EY027924 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOWNS, J CRAWFORD, MURPHY-ULLRICH, JOANNE E · 2018 to 2021
$1.8M
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY018926NEI NIH HHS R01 EY027924
6 · The paper itself

Abstract

BACKGROUND AND

objectiveBomb blast injuries exerts a shearing force on the air-tissue interfaces, causing devastating ocular injury from the blast wave. Improvised explosive devices (IEDs) are usually placed at different heights from the ground to induce more severe injury through ground blast reinforcement (GBR). However, there is still a lack of knowledge of the role of GBR and IED height from the ground on ocular biomechanics, and how they can affect the intraocular pressure (IOP) in the eye. This study aimed to estimate the IOP due to frontal IED explosion at different heights from the ground using a fluid-structure interaction model with and without GBR effects.

methodsA 2 kg IED was placed within 5 m of the victim at 5 different heights from the ground, including 0, 0.42, 0.85, 1.27, and 1.70 m. Two different blast formulations were used to simulate the IED explosion: (a) spherical airburst, with no amplification of the initial shock wave due to interaction with the ground-surface, and (b) hemispherical surface-burst, where the initial blast wave is immediately reflected and reinforced by the ground (GBR).

resultsResults revealed that the blast wave due to GBR reaches to the skull prior to the IED blast itself. The GBR also reached to the skull ∼ 0.6 ms earlier when the IED was on the ground compared to the height of 1.70 m. The highest and lowest IOPs of ∼ 17,000 and ∼ 15,000 mmHg were observed at the IED heights of 1.70 and 0 m from the ground considering GBR. However, when the role of the GBR is ignored, IOP of ∼ 9,000 mmHg was observed regardless of the IED height from the ground. The deformation in the apex of the cornea was higher when considering the GBR (∼ 0.75 cm) versus no GBR (∼ 0.65 cm). Considering GBR led to higher stresses and strains in the sclera.

conclusionsWhen the role of GBR was ignored, the results showed similar patterns and magnitudes of stresses and deformations in the skull and eye regardless of the height of the IED from the ground, which was not the case when GBR was considered. The findings of this study suggest the critical role of GBR in ocular blast simulations.

Indexed as

Blast InjuriesExplosionsBiomechanical PhenomenaBiophysicsEyeHumansFluid structure interactionGround blast reinforcementIED heightImprovised explosive devicesOptic nerve head

Identifiers

PMID34598082
PMCPMC8577623

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.