Evidence map›Paper›PMID 34597898›Full record

ArticlePsychoneuroendocrinology2021

Plasma metabolomic profiles associated with chronic distress in women.

Katherine H Shutta, Raji Balasubramanian, Tianyi Huang, Shaili C Jha, Oana A Zeleznik, Candyce H Kroenke, Lesley F Tinker, Jordan W Smoller, Ramon Casanova, Shelley S Tworoger and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Anxiety disorders: a cross-sectional study of clinical and biological associations.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Katherine H ShuttaDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, 010 Arnold House, 715 North Pleasant Street, Amherst, MA 01003, USA. Electronic address: kshutta@umass.edu.
Raji BalasubramanianDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, 010 Arnold House, 715 North Pleasant Street, Amherst, MA 01003, USA. Electronic address: rbalasub@umass.edu.
Tianyi HuangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: tih541@mail.harvard.edu.
Shaili C JhaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: sjha@hsph.harvard.edu.
Oana A ZeleznikChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: ozeleznik@bwh.harvard.edu.
Candyce H KroenkeDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA. Electronic address: candyce.h.kroenke@kp.org.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: ltinker@whi.org.
Jordan W SmollerDepartment of Psychiatry and Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: JSMOLLER@partners.org.
Ramon CasanovaWake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: casanova@wakehealth.edu.
Shelley S TworogerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cancer Epidemiology, Moffit Cancer Center, Tampa, FL, USA. Electronic address: Shelley.Tworoger@moffitt.org.
JoAnn E MansonChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: jmanson@rics.bwh.harvard.edu.
Clary B ClishBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Electronic address: clary@broadinstitute.org.
Kathryn M RexrodeHarvard Medical School, Boston, MA, USA; Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: KREXRODE@bwh.harvard.edu.
Susan E HankinsonDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, 010 Arnold House, 715 North Pleasant Street, Amherst, MA 01003, USA. Electronic address: shankinson@schoolph.umass.edu.
Laura D KubzanskyDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: lkubzans@hsph.harvard.edu.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Metabolomic profile of chronic distress in relation to diseases of aging across diverse populationsR01AG051600 · NIA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Susan E Hankinson, LAURA D KUBZANSKY · 2017 to 2026
$4.9M
Network Models for MetabolomicsR01LM013444 · NLM · UNIVERSITY OF MASSACHUSETTS AMHERST · PI BALASUBRAMANIAN, RAJI, SCHOLTENS, DENISE M · 2020 to 2023
$1.4M
NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA067262NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201300008CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL034594NIA NIH HHS R01 AG051600NIDDK NIH HHS P30 DK040561NLM NIH HHS R01 LM013444
6 · The paper itself

Abstract

Several forms of chronic distress including anxiety and depression are associated with adverse cardiometabolic outcomes. Metabolic alterations may underlie these associations. Whether these forms of distress are associated with metabolic alterations even after accounting for comorbid conditions and other factors remains unclear. Using an agnostic approach, this study examines a broad range of metabolites in relation to chronic distress among women. For this cross-sectional study of chronic distress and 577 plasma metabolites, data are from different substudies within the Women's Health Initiative (WHI) and Nurses' Health Studies (NHSI, NHSII). Chronic distress was characterized by depressive symptoms and other depression indicators in the WHI and NHSII substudies, and by combined indicators of anxiety and depressive symptoms in the NHSI substudy. We used a two-phase discovery-validation framework, with WHI (N = 1317) and NHSII (N = 218) substudies in the discovery phase (identifying metabolites associated with distress) and NHSI (N = 558) substudy in the validation phase. A differential network analysis provided a systems-level assessment of metabolomic alterations under chronic distress. Analyses adjusted for potential confounders and mediators (demographics, comorbidities, medications, lifestyle factors). In the discovery phase, 46 metabolites were significantly associated with depression measures. In validation, six of these metabolites demonstrated significant associations with chronic distress after adjustment for potential confounders. Among women with high distress, we found lower gamma-aminobutyric acid (GABA), threonine, biliverdin, and serotonin and higher C16:0 ceramide and 3-methylxanthine. Our findings suggest chronic distress is associated with metabolomic alterations and provide specific targets for future study of biological pathways in chronic diseases.

Indexed as

MetabolomicsPsychological DistressCross-Sectional StudiesFemaleHumansAnxietyChronic distressDepressionMetabolomicsNetwork analysisWomen’s health

Identifiers

PMID34597898
PMCPMC8547060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.