ArticleInternational journal of pediatric otorhinolaryngology2021
Tonsillectomy and hematologic malignancy: Should routine pediatric tonsillectomy specimens be sent to pathology?
Article in International journal of pediatric otorhinolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Clinical significance and diagnostic approach for paediatric unilateral tonsillar enlargement: insights from a retrospective analysis.Annals of the Royal College of Surgeons of England · 2025Article
- Assessing and enhancing pediatric residents' knowledge and skills in tracheostomy care through simulation-based training.Frontiers in pediatrics · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
objectivesRoutine pediatric tonsillectomy ± adenoidectomy (T ± A) is one of the most common procedures for children worldwide, accounting for approximately 2000 procedures per year at our institution. To determine the utility of pathologic analysis of routine, nonsuspicious pediatric tonsil specimens, we investigated the incidence of hematologic and lymphoid malignancy diagnosed at the time of or following T ± A.
methodsRetrospective review of patients 0-18 years undergoing T ± A between 2012 and 2020 with or without pathologic analysis.
resultsIncluded were 14,141 patients who underwent routine T ± A (mean age 11 ± 4.6 years, 48% female). Of these, tonsils of 2464 patients were sent to pathology, where zero were found to harbor malignancy. Seven patients (0.050%) developed malignancy after T ± A. Of these, 4 had unremarkable tonsils per pathology, and 3 did not have tonsils analyzed. There were 5 cases of Acute Lymphocytic Leukemia (ALL, 0.035%), 1 case of Acute Myeloid Leukemia (0.007%), and 1 case of Lymphoma (0.007%). The average length of time from T ± A to diagnosis was 2.4 ± 1.8 years.
conclusionNo cases of occult malignancy were identified in specimens from routine T ± A with pathologic analysis, even among patients who later developed malignancy. This study suggests that sending routine pediatric T ± A specimens for formal pathologic analysis is an inefficient use of resources without appreciably improving the quality and safety of patient care.
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