ArticleCells & development2021
The zebrafish presomitic mesoderm elongates through compaction-extension.
Article in Cells & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.The EMBO journal · 2026Article
- Modelling co-development between the somites and neural tube in human trunk-like structures.Nature cell biology · 2025Article
- Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.Cell · 2025Review
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- Article
- The physical roles of different posterior tissues in zebrafish axis elongation.Nature communications · 2025Article
- Spinal cord elongation enables proportional regulation of the zebrafish posterior body.Development (Cambridge, England) · 2025Article
- Approximated gene expression trajectories for gene regulatory network inference on cell tracks.iScience · 2024Article
- A human pluripotent stem cell-based somitogenesis model using microfluidics.Cell stem cell · 2024Article
- Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: integrating viscous modeling and experimental approaches.Development (Cambridge, England) · 2024Article
- Article
- Constructing the pharyngula: Connecting the primary axial tissues of the head with the posterior axial tissues of the tail.Cells & development · 2023Review
- Automated time-lapse data segmentation reveals in vivo cell state dynamics.Science advances · 2023Article
- Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation.Nature communications · 2022Article
- Regeneration of the human segmentation clock in somitoids in vitro.The EMBO journal · 2022Article
- Mesoderm induction and patterning: Insights from neuromesodermal progenitors.Seminars in cell & developmental biology · 2022Review
- The unappreciated generative role of cell movements in pattern formation.Royal Society open science · 2022Review
- In preprints: the problem of producing precise patterns.Development (Cambridge, England) · 2022Article
- Sculpting with stem cells: how models of embryo development take shape.Development (Cambridge, England) · 2021Article
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Authors and funding
3 authors.
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Abstract
In vertebrate embryos the presomitic mesoderm becomes progressively segmented into somites at the anterior end while extending along the anterior-posterior axis. A commonly adopted model to explain how this tissue elongates is that of posterior growth, driven in part by the addition of new cells from uncommitted progenitor populations in the tailbud. However, in zebrafish, much of somitogenesis is associated with an absence of overall volume increase, and posterior progenitors do not contribute new cells until the final stages of somitogenesis. Here, we perform a comprehensive 3D morphometric analysis of the paraxial mesoderm and reveal that extension is linked to a volumetric decrease and an increase in cell density. We also find that individual cells decrease in volume over successive somite stages. Live cell tracking confirms that much of this tissue deformation occurs within the presomitic mesoderm progenitor zone and is associated with non-directional rearrangement. Taken together, we propose a compaction-extension mechanism of tissue elongation that highlights the need to better understand the role tissue intrinsic and extrinsic forces in regulating morphogenesis.
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