ArticleContemporary clinical trials2021
Effects of financial incentives on volunteering for clinical trials: A randomized vignette experiment.
Article in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Drivers of Research Participation Among Racially and Ethnically Underrepresented Women: Insights from Semi-Structured Interviews.Journal of racial and ethnic health disparities · 2026Article
- The ethical permissibility of financial incentives.Medicine, health care, and philosophy · 2026Article
- Evaluating acute image ordering for real-world patient cases via language model alignment with radiological guidelines.Communications medicine · 2025Article
- Supporting rapid innovation in research data capture and management: the REDCap external module framework.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Impact of financial compensation on enrollment and participation in a remote, mobile-app based research study.Journal of clinical and translational science · 2024Article
- Pet owner perspectives, motivators and concerns about veterinary biobanking.Frontiers in veterinary science · 2024Article
- Volunteering for Infection: Participant Perspectives on a Hepatitis C Virus Controlled Human Infection Model.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Development and pilot implementation of guidelines for culturally tailored research recruitment materials for African Americans and Latinos.BMC medical research methodology · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundFinancial incentives may aid recruitment to clinical trials, but evidence regarding risk/burden-driven variability in participant preferences for incentives is limited. We developed and tested a framework to support real-world decisions on recruitment budget.
methodsWe included two phases: an Anchoring Survey, to ensure we could capture perceived unpleasantness on a range of life events, and a Vignette Experiment, to explore relationships between financial incentives and participants' perceived risk/burden and willingness to participate in high- and low-risk/burden versions of five vignettes drawn from common research activities. We compared vignette ratings to identify similarly rated life events from the Anchoring Survey to contextualize ratings of study risk.
resultsIn our Anchoring Survey (n = 643), mean ratings (scale 1 = lowest risk/burden to 5 = highest risk/burden) indicated that the questions made sense to participants, with highest risk assigned to losing house in a fire (4.72), and lowest risk assigned to having blood pressure taken (1.13). In the Vignette Experiment (n = 534), logistic regression indicated that amount of offered financial incentive and perceived risk/burden level were the top two drivers of willingness to participate in four of the five vignettes. Comparison of event ratings in the Anchoring Survey with the Vignette Experiment ratings suggested reasonable concordance on severity of risk/burden.
conclusionsWe demonstrated feasibility of a framework for assessing participant perceptions of risk for study activities and discerned directionality of relationship between financial incentives and willingness to participate. Future work will explore use of this framework as an evidence-gathering approach for gauging appropriate incentives in real-world study contexts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.