Evidence map›Paper›PMID 34597762›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

Clinical investigation of intestinal fatty acid-binding protein (I-FABP) as a biomarker of SARS-CoV-2 infection.

Rafael Simone Saia, Humberto Giusti, Fábio Luis-Silva, Karina de Jesus Bonicenha Pedroso, Maria Auxiliadora-Martins, Karen Mirna Loro Morejón, Augusto Marcussi Degiovani, Márcia Regina Cadelca, Anibal Basile-Filho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Rafael Simone SaiaLaboratory of Intestinal Pathophysiology, Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address: rssaia@fmrp.usp.br.
Humberto GiustiLaboratory of Intestinal Pathophysiology, Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Fábio Luis-SilvaDivision of Intensive Care Medicine, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Intensive Care Unit, Fundação Hospital Santa Lydia, Ribeirão Preto, São Paulo, Brazil.
Karina de Jesus Bonicenha PedrosoHospital Unimed Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
Maria Auxiliadora-MartinsDivision of Intensive Care Medicine, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Karen Mirna Loro MorejónHospital Unimed Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
Augusto Marcussi DegiovaniIntensive Care Unit, Santa Casa de Misericórdia, Ribeirão Preto, São Paulo, Brazil.
Márcia Regina CadelcaIntensive Care Unit, Hospital e Maternidade Santa Isabel, Jaboticabal, São Paulo, Brazil.
Anibal Basile-FilhoDivision of Intensive Care Medicine, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Universidade de São Paulo · BRClinics Hospital of Ribeirão Preto · BRHospital Santa Paula · BRIrmandade da Santa Casa de Misericórdia de São Paulo · BRUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSARS-CoV-2 exhibits tropism for the gastrointestinal tract; however, lesions in enterocytes and their correlation with disease severity and patient prognosis are still unknown.

methodsSARS-CoV-2 patients were enrolled in 5 medical centres in São Paulo, Brazil and their clinical characteristics and laboratory findings recorded. At admission, day 7 and day 14 of hospitalisation, plasma and urine samples were collected, and cytokine levels and intestinal fatty acid-binding protein (I-FABP) concentrations measured.

resultsCOVID-19 patients displayed ≈48-, 74- and 125-fold increased urinary I-FABP levels at admission (n=283; P<0.001), day 7 (n=142; P<0.01) and day 14 (n=75; P<0.01) of hospitalisation. Critically ill patients and nonsurvivors showed higher I-FABP concentrations compared with patients with less severe illness. At admission, infected patients demonstrated enhanced production of plasma interferon (IFN)-γ and interleukin (IL)-6. The receiver operating characteristic curve suggested I-FABP as a biomarker for COVID-19 disease severity at admission (P<0.0001; Youden index=6.89; area under the curve=0.699). Patients with I-FABP ≥6.89 showed higher IL-6 and C-reactive protein levels (P<0.001) at admission and had a prolonged length of hospital stay.

conclusionsOur findings revealed damage to enterocytes in SARS-CoV-2 infection, which is associated with illness severity, poor prognosis and exacerbated inflammatory response.

Indexed as

COVID-19BiomarkersBrazilC-Reactive ProteinEnterocytesFatty Acid-Binding ProteinsHumansInterferon-gammaInterleukin-6Prospective StudiesBiomarkersC-Reactive ProteinFABP2 protein, humanFatty Acid-Binding ProteinsIFNG protein, humanIL6 protein, humanInterferon-gammaInterleukin-6COVID-19cytokinesinflammationinterleukin-6intestinal epithelial cells

Identifiers

PMID34597762
PMCPMC8479553
OpenAlexW3201730453

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.