Evidence map›Paper›PMID 34597688›Full record

ReviewThe American journal of the medical sciences2021

Mechanical Power: A New Concept in Mechanical Ventilation.

Robin Paudel, Christine A Trinkle, Christopher M Waters, Lauren E Robinson, Evan Cassity, Jamie L Sturgill, Richard Broaddus, Peter E Morris

7 registry-linked trialsAbstract readReview
In one paragraph

Review in The American journal of the medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06400095 recruitingnot on this mapstarted 2023, after this paper: background citation

Occlusion Pressure at 100 Msec, TCe ( Expiratory Time Constant ), Stress Energy Density, Mechanical Power, Ventilatory Ratio and C20/Cdyn in Predicting Outcomes in Patients With Moderately Severe ARDS, Who Are on Mechanical Ventilation

TypeobservationalSponsorCentraCareRan2023 to 2025Enrolled50ConditionsARDS, Mechanical PowerArmsPoccl, Time constant, driving pressure
NCT06493929 unknown statusnot on this mapstarted 2024, after this paper: background citation

Mechanical Power As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients :Prospective Cohort Study.

TypeobservationalSponsorAssiut UniversityRan2024 to 2026Enrolled84ConditionsMechanical PowerArmsChest ultrasound, Calculation of Mechanical Power on the first day of intubation and before First trial of weaning:
NCT06510517 unknown statusnot on this mapstarted 2024, after this paper: background citation

Mechanical Power Versus Diaphragmatic Excursion As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients: Prospective Cohort Study

Typeobservational_patient_registrySponsorAssiut UniversityRan2024 to 2026Enrolled84ConditionsMechanical PowerArmsCalculation of Mechanical Power., Measurement Diaphragmatic Excursion after first SBT
NCT06625099 completednot on this mapstarted 2024, after this paper: background citation

Comparison of the Effects of Different Positive Expiratory Pressure Levels on Patient Oxygenation and Mechanical Power Values in Laparoscopic Surgeries

TypeobservationalSponsorKocaeli City HospitalRan2024 to 2025Enrolled101ConditionsMechanical Ventilation, Mechanical Power, Optimum PEEP, Laparoscopic Abdominal SurgeryArmsMechanical Ventilation (MV) with Low PEEP, Mechanical Ventilation (MV) with Optimum PEEP
NCT07024433 narecruitingnot on this mapstarted 2025, after this paper: background citation

Tubeless Anesthesia in Preventing Contralateral Lung Complications in Patients Undergoing Single-Port Thoracoscopic Surgery for Early-Stage Lung Cancer: A Single-Center, Prospective, Open-Label, Randomized Controlled Trial

TypeinterventionalSponsorFujian Medical University Union HospitalRan2025 to 2027Enrolled224ConditionsLung Cancer PatientsArmsTubeless anesthesia, Traditional tracheal intubation
NCT07188350 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neuromuscular Electrical Stimulation of Lower Limbs in Patients Undergoing Invasive Mechanical Ventilation: Randomized Clinical Trial

TypeinterventionalSponsorHospital Moinhos de VentoRan2025 to 2027Enrolled150ConditionsMechanical Ventilation, Critical Illness, Intensive Care Unit Patients, Muscle Weakness ConditionArmsConventional Physical Therapy, Neuromuscular Electrical Stimulation (NMES)
NCT07639489 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association of Intraoperative Mechanical Power With Postoperative Pulmonary Complications and Prolonged Mechanical Ventilation in Coronary Artery Bypass Graft Surgery

TypeobservationalSponsorFusun GozenRan2026 to 2026Enrolled110ConditionsPostoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG), Prolonged Mechanical VentilationArmsIntraoperative Mechanical Ventilation Monitoring
3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Bench evidence, bedside uncertainty: hyperoxia, mechanical ventilation and lung injury.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  8. Article
  9. Article
  10. The role of mechanical power in lung ventilation for the prevention of ventilator-induced lung injury: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Bridging brain and lung: optimizing mechanical ventilation in acute brain injury.Journal of anesthesia, analgesia and critical care · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robin PaudelDivision of Pulmonary, Critical Care, and Sleep Medicine, Mayo Clinic Health System, Franciscan Healthcare in La Crosse, La Crosse, WI, USA. Electronic address: paudel.robin@mayo.edu.
Christine A TrinkleDepartment of Mechanical Engineering, University of Kentucky College of Engineering, Lexington, KY, USA.
Christopher M WatersDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA.
Lauren E RobinsonLibrary Administration, University of Kentucky, Lexington, KY, USA.
Evan CassityDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Jamie L SturgillDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Richard BroaddusDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Peter E MorrisDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.

Funding

Biophysical Mechanisms of Hyperoxia-Induced Lung InjuryR01HL151419 · NHLBI · UNIVERSITY OF KENTUCKY · PI WATERS, CHRISTOPHER M · 2020 to 2023
$2.1M
ASK1 and Ventilator-Induced Lung InjuryR01HL131526 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WATERS, CHRISTOPHER M · 2017 to 2020
$1.7M
NHLBI NIH HHS R01 HL131526NHLBI NIH HHS R01 HL151419
6 · The paper itself

Abstract

Mechanical ventilation is a potentially life-saving therapy for patients with acute lung injury, but the ventilator itself may cause lung injury. Ventilator-induced lung injury (VILI) is sometimes an unfortunate consequence of mechanical ventilation. It is not clear however how best to minimize VILI through adjustment of various parameters including tidal volume, plateau pressure, driving pressure, and positive end expiratory pressure (PEEP). No single parameter provides a clear indication for onset of lung injury attributable exclusively to the ventilator. There is currently interest in quantifying how static and dynamic parameters contribute to VILI. One concept that has emerged is the consideration of the amount of energy transferred from the ventilator to the respiratory system per unit time, which can be quantified as mechanical power. This review article reports on recent literature in this emerging field and future roles for mechanical power assessments in prospective studies.

Indexed as

Respiratory Distress SyndromeVentilator-Induced Lung InjuryHumansProspective StudiesRespiration, ArtificialTidal VolumeAcute respiratory distress syndromesMechanical energyMechanical powerMechanical ventilatorVentilator induced lung injury

Identifiers

PMID34597688
PMCPMC8688297

What OpenQuestion holds

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Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.