ArticleCell host & microbe2021
Prophages encode phage-defense systems with cognate self-immunity.
Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026Review
- The role of phages in plant-associated microbial communities.Essays in biochemistry · 2026Review
- The value of a prophage-borne defense system in phage-phage competition.PLoS computational biology · 2026Article
- From hijackers to architects: the role of prophages in bacterial genome evolution.Journal of bacteriology · 2026Review
- Comparative genomics reveals high prophage diversity and horizontal gene transfer of effectors and phage defence systems in theMicrobial genomics · 2026Article
- Article
- Conditional activation of Cas13 enforces lysogeny in a native type VI-A CRISPR host.Nature microbiology · 2026Article
- Diverse Temperate Coliphages of the Urinary Tract.Viruses · 2026Article
- Genomic landscape of biosynthetic gene clusters in Iranian extremophiles reveals prolific metabolite potential, prophage associations, and integrated defensive-metabolic islands.BMC microbiology · 2026Article
- Prophage-encoded RexAB-type phage defense system in Pseudomonas putida.Scientific reports · 2026Article
- Whole-Genome Sequencing and Pathogenic Characterization of aMicroorganisms · 2026Article
- Genomics of Irish swine-derivedMicrobial genomics · 2026Article
- Prophage diversity in poultry-associatedFrontiers in microbiology · 2026Article
- Structural and functional relevance of the DUF4352 domain in antiviral immunity and physiology of mycobacteria.Nucleic acids research · 2025Article
- Article
- A prophage intercepts pathogenic activity of infecting phage for defense.Cell host & microbe · 2025Article
- Evolutionary selection of trimethoprim-resistantScience advances · 2025Article
- YprA family helicases provide the missing link between diverse prokaryotic immune systems.bioRxiv : the preprint server for biology · 2025Article
- OLD amputates the anticodon arm of tRNAs during P2-Lambda interference.Nucleic acids research · 2025Article
- Why do bacteria accumulate antiphage defence systems?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
25 more citing papers are in PubMed but not listed here.
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11 authors.
Funding
Abstract
Temperate phages are pervasive in bacterial genomes, existing as vertically inherited islands termed prophages. Prophages are vulnerable to predation of their host bacterium by exogenous phages. Here, we identify BstA, a family of prophage-encoded phage-defense proteins in diverse Gram-negative bacteria. BstA localizes to sites of exogenous phage DNA replication and mediates abortive infection, suppressing the competing phage epidemic. During lytic replication, the BstA-encoding prophage is not itself inhibited by BstA due to self-immunity conferred by the anti-BstA (aba) element, a short stretch of DNA within the bstA locus. Inhibition of phage replication by distinct BstA proteins from Salmonella, Klebsiella, and Escherichia prophages is generally interchangeable, but each possesses a cognate aba element. The specificity of the aba element ensures that immunity is exclusive to the replicating prophage, preventing exploitation by variant BstA-encoding phages. The BstA protein allows prophages to defend host cells against exogenous phage attack without sacrificing the ability to replicate lytically.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.