ArticleHuman brain mapping2021
The trajectory of the medial longitudinal fasciculus in the human brain: A diffusion imaging-based tractography study.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Pupil-sparing partial oculomotor palsy with ipsilateral medial longitudinal fasciculus involvement: A novel midbrain infarct phenotype-a case report.The Journal of international medical research · 2025Article
- Incidence, Clinician Misdiagnosis Rate, Radiologist Missed Diagnosis Rate, and Lesion Distribution of Isolated Medial Longitudinal Fasciculus Infarction: A Retrospective Study.International journal of general medicine · 2025Article
- Correlation of diffusion tensor tractography with obstructive sleep apnea severity.Brain and behavior · 2024Article
- The effects of the dialysis on the white matter tracts in patients with end-stage renal disease using differential tractography study.Scientific reports · 2023Article
- Correlation of Diffusion Tensor Tractography with Restless Legs Syndrome Severity.Brain sciences · 2023Article
- Automatic oculomotor nerve identification based on data-driven fiber clustering.Human brain mapping · 2022Article
- Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study.Frontiers in human neuroscience · 2022Article
- The trajectory of the medial longitudinal fasciculus in the human brain: A diffusion imaging-based tractography study.Human brain mapping · 2021Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to investigate the trajectory of medial longitudinal fasciculus (MLF) and explore its anatomical relationship with the oculomotor nerve using tractography technique. The MLF and oculomotor nerve were reconstructed at the same time with preset three region of interests (ROIs): one set at the area of rostral midbrain, one placed on the MLF area at the upper pons, and one placed at the cisternal part of the oculomotor nerve. This mapping protocol was tested in an HCP-1065 template, 35 health subjects from Massachusetts General Hospital (MGH), 20 healthy adults and 6 brainstem cavernous malformation (BCM) patients with generalized q-sampling imaging (GQI)-based tractography. Finally, the 200 μm brainstem template from Center for In Vivo Microscopy, Duke University (Duke CIVM), was used to validate the trajectory of reconstructed MLF. The MLF and oculomotor nerve were reconstructed in the HCP-1065 template, 35 MGH health subjects, 20 healthy adults and 6 BCM patients. The MLF was in conjunction with the ipsilateral mesencephalic part of the oculomotor nerve. The displacement of MLF was identified in all BCM patients. Decreased QA, RDI and FA were found in the MLF of lesion side, indicating axonal loss and/or edema of displaced MLF. The reconstructed MLF in Duke CIVM brainstem 200 μm template corresponded well with histological anatomy. The MLF and oculomotor nerve were visualized accurately with our protocol using GQI-based fiber tracking. This GQI-based tractography is an important tool in the reconstruction and evaluation of MLF.
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