Evidence map›Paper›PMID 34597235›Full record

ArticleRadiographics : a review publication of the Radiological Society of North America, Inc2021

Radiomics in Oncology: A Practical Guide.

Joshua D Shur, Simon J Doran, Santosh Kumar, Derfel Ap Dafydd, Kate Downey, James P B O'Connor, Nikolaos Papanikolaou, Christina Messiou, Dow-Mu Koh, Matthew R Orton

Abstract read
In one paragraph

Article in Radiographics : a review publication of the Radiological Society of North America, Inc, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

233 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  3. Role of Radiomics to Predict Disease Recurrence in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
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  15. Differentiating high- and low-grade serous ovarian carcinoma using radiomics: a pilot study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
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  20. A Brainstem Radiomics Framework to Distinguish Progressive Supranuclear Palsy from Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article

173 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joshua D ShurFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).ORCID 0000-0002-4569-4785
Simon J DoranFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).ORCID 0000-0001-8569-9188
Santosh KumarFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).ORCID 0000-0002-6362-0616
Derfel Ap DafyddFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).
Kate DowneyFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).ORCID 0000-0002-2498-4257
James P B O'ConnorFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).
Nikolaos PapanikolaouFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).ORCID 0000-0003-3298-2072
Christina MessiouFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).ORCID 0000-0002-0557-9379
Dow-Mu KohFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).
Matthew R OrtonFrom the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Sutton, England (J.D.S., D.a.D., K.D., N. P., C.M., D.M.K.); Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, England (S.J.D., S.K., J.P.B.O., N. P., C.M., D.M.K., M.R.O.); and Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal (N.P.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiomics refers to the extraction of mineable data from medical imaging and has been applied within oncology to improve diagnosis, prognostication, and clinical decision support, with the goal of delivering precision medicine. The authors provide a practical approach for successfully implementing a radiomic workflow from planning and conceptualization through manuscript writing. Applications in oncology typically are either classification tasks that involve computing the probability of a sample belonging to a category, such as benign versus malignant, or prediction of clinical events with a time-to-event analysis, such as overall survival. The radiomic workflow is multidisciplinary, involving radiologists and data and imaging scientists, and follows a stepwise process involving tumor segmentation, image preprocessing, feature extraction, model development, and validation. Images are curated and processed before segmentation, which can be performed on tumors, tumor subregions, or peritumoral zones. Extracted features typically describe the distribution of signal intensities and spatial relationship of pixels within a region of interest. To improve model performance and reduce overfitting, redundant and nonreproducible features are removed. Validation is essential to estimate model performance in new data and can be performed iteratively on samples of the dataset (cross-validation) or on a separate hold-out dataset by using internal or external data. A variety of noncommercial and commercial radiomic software applications can be used. Guidelines and artificial intelligence checklists are useful when planning and writing up radiomic studies. Although interest in the field continues to grow, radiologists should be familiar with potential pitfalls to ensure that meaningful conclusions can be drawn.

Indexed as

Artificial IntelligenceImage Processing, Computer-AssistedDiagnostic ImagingHumansMedical OncologyRadiography

Identifiers

PMID34597235
PMCPMC8501897

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.