ArticleScience advances2021
Capillary flow control in lateral flow assays via delaminating timers.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Rapid-Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Revolutionizing Healthcare With Paper-Based Nucleic Acid Testing.Exploration (Beijing, China) · 2026Review
- Interpretable machine learning and signal processing for automated reading and quality control of lateral flow tests for schistosomiasis.Nature communications · 2026Article
- Rapid Filtration Allows Ultrafast Measurement of Antibody and Nanoparticle Capture in Porous Matrices: Implications for Lateral Flow Immunoassays and Membrane Chromatography.ACS applied nano materials · 2026Article
- Paper-based microfluidics for wearable soft bioelectronics.Lab on a chip · 2026Review
- Interpretable machine learning and signal processing for automated reading and quality control of lateral flow tests for schistosomiasis.medRxiv : the preprint server for health sciences · 2025Article
- Machine learning in point-of-care testing: innovations, challenges, and opportunities.Nature communications · 2025Review
- Rapid and facile detection of Mycoplasma pneumoniae 16S rRNA based on CHA-FICA system.Mikrochimica acta · 2025Article
- Integrated and streamlined microfluidic device for molecular diagnosis of pathogen through direct PCR amplification.Heliyon · 2025Article
- Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding.Microsystems & nanoengineering · 2025Article
- Development of an Antigen Capture Lateral Flow Immunoassay for the Detection ofDiagnostics (Basel, Switzerland) · 2024Article
- Review
- Sample-to-answer platform for the clinical evaluation of COVID-19 using a deep learning-assisted smartphone-based assay.Nature communications · 2023Article
- Lateral flow immunoassay for small-molecules detection in phytoproducts: a review.Journal of natural medicines · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lateral flow assays (LFAs) use capillary flow of liquids for simple detection of analytes. While useful for spontaneously wicking samples, the capillary flow inherently limits performing complex reactions that require timely application of multiple solutions. Here, we introduce a technique to control capillary flow on paper by imprinting roadblocks on the flow path with water-insoluble ink and using the gradual formation of a void between a wetted paper and a sheath polymer tape to create timers. Timers are drawn at strategic nodes to hold the capillary flow for a desired period and thereby enable multiple liquids to be introduced into multistep chemical reactions following a programmed sequence. Using our technique, we developed (i) an LFA with built-in signal amplification to detect human chorionic gonadotropin with an order of magnitude higher sensitivity than the conventional assay and (ii) a device to extract DNA from bodily fluids without relying on laboratory instruments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.