Evidence map›Paper›PMID 34597134›Full record

ArticleScience advances2021

Liquid crystal-based open surface microfluidics manipulate liquid mobility and chemical composition on demand.

Yang Xu, Adil M Rather, Yuxing Yao, Jen-Chun Fang, Rajdeep S Mamtani, Robert K A Bennett, Richard G Atta, Solomon Adera, Uroš Tkalec, Xiaoguang Wang

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Drop Friction on Textured Lubricant-Coated Surfaces.ACS applied materials & interfaces · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Janus Charged Droplet Manipulation Mediated by Invisible Charge Walls.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Bioinspired liquid-infused surface for biomedical and biosensing applications.Frontiers in bioengineering and biotechnology · 2022
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang XuWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-9945-7507
Adil M RatherWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-9433-843X
Yuxing YaoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-0337-6372
Jen-Chun FangWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.
Rajdeep S MamtaniWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.
Robert K A BennettDepartment of Electrical and Computer Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0001-7427-8724
Richard G AttaWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.
Solomon AderaDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3249-301X
Uroš TkalecInstitute of Biophysics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.ORCID 0000-0003-0552-0518
Xiaoguang WangWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-4079-9596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to control both the mobility and chemical compositions of microliter-scale aqueous droplets is an essential prerequisite for next-generation open surface microfluidics. Independently manipulating the chemical compositions of aqueous droplets without altering their mobility, however, remains challenging. In this work, we address this challenge by designing a class of open surface microfluidic platforms based on thermotropic liquid crystals (LCs). We demonstrate, both experimentally and theoretically, that the unique positional and orientational order of LC molecules intrinsically decouple cargo release functionality from droplet mobility via selective phase transitions. Furthermore, we build sodium sulfide–loaded LC surfaces that can efficiently precipitate heavy metal ions in sliding water droplets to final concentration less than 1 part per million for more than 500 cycles without causing droplets to become pinned. Overall, our results reveal that LC surfaces offer unique possibilities for the design of novel open surface fluidic systems with orthogonal functionalities.

Identifiers

PMID34597134
PMCPMC10938512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.