Evidence map›Paper›PMID 34596868›Full record

ArticleJournal of neurovirology2021

Clinical use of steroids in viral central nervous system (CNS) infections: three challenging cases.

Adam Kroopnick, Dan Tong Jia, Kathryn Rimmer, Vivian S Namale, Carla Kim, Ugoada Ofoezie, Kiran T Thakur

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Powassan Virus Infections: A Systematic Review of Published Cases.Tropical medicine and infectious disease · 2023
    Review
  2. Powassan Virus Encephalitis.Infectious disease clinics of North America · 2022
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adam KroopnickDepartment of Neurology, Columbia University Irving Medical Center-New York Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Dan Tong JiaNorthwestern University School of Medicine, 420 E Superior St, Chicago, Illinois, 60611, USA.
Kathryn RimmerDepartment of Neurology, Columbia University Irving Medical Center-New York Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Vivian S NamaleDepartment of Neurology, Columbia University Irving Medical Center-New York Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Carla KimDepartment of Neurology, Columbia University Irving Medical Center-New York Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Ugoada OfoezieDepartment of Neurology, Columbia University Irving Medical Center-New York Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Kiran T ThakurDepartment of Neurology, Columbia University Irving Medical Center-New York Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA. ktt2115@cumc.columbia.edu.ORCID 0000-0003-0050-0323
NewYork–Presbyterian Hospital · USNorthwestern University · US

Funding

Innovative PK/PD Approaches to Optimize TBM Treatment in Children (PATCH Study)R01HD074944 · NICHD · JOHNS HOPKINS UNIVERSITY · PI DOOLEY, KELLY E. · 2014 to 2019
$2.5M
Clinical Impact of Early Pathogen Identification in Acute Neurological InfectionsK23NS105935 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI THAKUR, KIRAN TERESA · 2018 to 2022
$930k
NICHD NIH HHS R01 HD074944NINDS NIH HHS K23 NS105935
6 · The paper itself

Abstract

The role of adjunctive corticosteroids in reducing morbidity and mortality of viral CNS infections remains poorly defined. Clinicians are often left in a quagmire regarding steroid use in complex and rapidly evolving viral CNS infections. Limited studies have explored the underlying mechanisms behind the potential benefit of steroids. Here, we describe steroid use in three cases of viral CNS disease: varicella zoster virus (VZV), Powassan virus, and influenza A-associated acute necrotizing encephalopathy.

Indexed as

Central Nervous System Viral DiseasesHerpes ZosterAdrenal Cortex HormonesCentral Nervous SystemHerpesvirus 3, HumanHumansSteroidsAdrenal Cortex HormonesSteroidsAdjunctive corticosteroidsSteroid treatmentTreatment strategyViral CNS infections

Identifiers

PMID34596868
OpenAlexW3202265821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.