Evidence map›Paper›PMID 34596747›Full record

Trial reportSurgical endoscopy2022

Warm and humidified insufflation gas during gynecologic laparoscopic surgery reduces postoperative pain in predisposed patients-a randomized, controlled multi-arm trial.

Markus Breuer, Julia Wittenborn, Rolf Rossaint, Julia Van Waesberghe, Ana Kowark, Deborah Mathei, András Keszei, Svetlana Tchaikovski, Magdalena Zeppernick, Felix Zeppernick and 4 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Markus Breuer *Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Julia Wittenborn *Department of Gynecology and Obstetrics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Rolf RossaintDepartment of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Julia Van WaesbergheDepartment of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Ana KowarkDepartment of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Deborah MatheiDepartment of Gynecology and Obstetrics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
András KeszeiDepartment of Medical Statistics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Svetlana TchaikovskiDepartment of Gynecology and Obstetrics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Magdalena ZeppernickDepartment of Gynecology and Obstetrics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Felix ZeppernickDepartment of Gynecology and Obstetrics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Elmar StickelerDepartment of Gynecology and Obstetrics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Norbert ZorembaDepartment of Anesthesiology and Intensive Care, St Elisabeth Hospital, Stadtring Kattenstroth 130, 33332, Gütersloh, Germany.
Ivo Meinhold-Heerlein *Department of Gynecology and Obstetrics, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Christian Bruells *Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. cbruells@ukaachen.de.
RWTH Aachen University · DEUniversity of Giessen · DESt. Elisabeth-Hospital Bochum · DEUniversitätsklinikum Gießen und Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative pain remains a common problem in gynecologic laparoscopy, especially in head zone-related regions, triggered by intra-abdominal pressure during capnoperitoneum. Humidified and prewarmed insufflation gas may ameliorate pain and be beneficial.

methodsThis prospective randomized controlled parallel group multi-arm single-center study investigated the effects of temperature and humidity of insufflation gas on postoperative pain during gynecologic laparoscopy with a duration ≥ 60 min. Female participants (18-70 years) were blinded and randomly assigned-computer generated-to either insufflation with dry cold CO

results150 participants were randomized. Compared to group "AIR" (n = 48), there was significantly less pain in group "HUMI +" (n = 48) in the recovery room (- 1.068; 95% CI - 2.08 to - 0.061), as well as significantly less ibuprofen use at day two (- 0.5871 g ± 0.258; p-value = 0.0471). Other variables did not change significantly. Stratification for presence of endometriosis or non-previous abdominal surgery in patient history revealed significantly less pain in both groups "HUMI" (n = 50) and "HUMI +" versus group "AIR." Related side effects were not noted.

conclusionIn the overall population, the use of warm, humidified insufflation gas did not yield clinically relevant effects; however, in predisposed patients with endometriosis and who could otherwise expect high pain levels, warm and humidified gas may be beneficial.

Indexed as

EndometriosisInsufflationLaparoscopyCarbon DioxideFemaleHot TemperatureHumansHumidityPostoperative PainProspective StudiesCarbon DioxideGynecologyLaparoscopyPostoperative painWarm humidified insufflation gas

Identifiers

PMID34596747
PMCPMC9085687
OpenAlexW3204268526

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.