Evidence map›Paper›PMID 34596325›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Reconfigurable Two-Dimensional DNA Lattices: Static and Dynamic Angle Control.

Wen Wang, Chunyu Chen, Simon Vecchioni, Tianqing Zhang, Chengxian Wu, Yoel P Ohayon, Ruojie Sha, Nadrian C Seeman, Bryan Wei

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Ligation-induced DNA self-assembly.Nucleic acids research · 2025
    Article
  4. Article
  5. Article
  6. Crystalline Assemblies of DNA Nanostructures and Their Functional Properties.Angewandte Chemie (International ed. in English) · 2025
    Review
  7. Article
  8. Engineering tertiary chirality in helical biopolymers.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Dynamics of DNA Origami Lattices.Bioconjugate chemistry · 2023
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen WangSchool of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Chunyu ChenSchool of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Simon VecchioniDepartment of Chemistry, New York University, New York, New York, 10003, USA.
Tianqing ZhangSchool of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Chengxian WuSchool of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Yoel P OhayonDepartment of Chemistry, New York University, New York, New York, 10003, USA.
Ruojie ShaDepartment of Chemistry, New York University, New York, New York, 10003, USA.
Nadrian C SeemanDepartment of Chemistry, New York University, New York, New York, 10003, USA.
Bryan WeiSchool of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.ORCID 0000-0003-2857-9352

Funding

Physical Chemistry of Recombinational IntermediatesR37GM029554 · NIGMS · NEW YORK UNIVERSITY · PI SEEMAN, NADRIAN C. · 2005 to 2012
$2.7M
PHYSICAL CHEMISTRY OF RECOMBINATIONAL INTERMEDIATESR01GM029554 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI SEEMAN, NADRIAN C. · 1985 to 2004
$1.4M
Army Research Office W911NF-1110024Department of Energy DESC0007991Gordon and Betty Moore Foundation GBMF3849National Natural Science Foundation of China 31770926National Science Foundation CCF-1117210National Science Foundation CHE-1708776National Science Foundation CTS1120890National Science Foundation EFRI-1332411NIGMS NIH HHS GM-29554NIGMS NIH HHS R01 GM029554NIGMS NIH HHS R37 GM029554Office of Naval Research N000140911118Office of Naval Research N000141110729Postdoctoral Research Foundation of China 2018M631448
6 · The paper itself

Abstract

Branched DNA motifs serve as the basic construction elements for all synthetic DNA nanostructures. However, precise control of branching orientation remains a key challenge to further heighten the overall structural order. In this study, we use two strategies to control the branching orientation. The first one is based on immobile Holliday junctions which employ specific nucleotide sequences at the branch points which dictate their orientation. The second strategy is to use angle-enforcing struts to fix the branching orientation with flexible spacers at the branch points. We have also demonstrated that the branching orientation control can be achieved dynamically, either by canonical Watson-Crick base pairing or non-canonical nucleobase interactions (e.g., i-motif and G-quadruplex). With precise angle control and feedback from the chemical environment, these results will enable novel DNA nanomechanical sensing devices, and precisely-ordered three-dimensional architectures.

Indexed as

DNANanostructuresNanotechnologyNucleotide MotifsDNAangle controlbranching orientationDNA nanostructuresjunction motifself-assembly

Identifiers

PMID34596325
PMCPMC9649588

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.