Evidence map›Paper›PMID 34596323›Full record

ArticleHIV medicine2022

Children living with HIV in Europe: do migrants have worse treatment outcomes?

Elizabeth Chappell, Malte Kohns Vasconcelos, Ruth L Goodall, Luisa Galli, Tessa Goetghebuer, Antoni Noguera-Julian, Laura C Rodrigues, Henriette Scherpbier, Colette Smit, Alasdair Bamford and 18 more

Abstract read
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Elizabeth ChappellMRC Clinical Trials Unit at UCL, London, UK.ORCID 0000-0003-1053-6434
Malte Kohns VasconcelosDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Ruth L GoodallMRC Clinical Trials Unit at UCL, London, UK.
Luisa GalliInfectious Disease Unit, Department of Health Sciences, Meyer Children's Hospital, University of Florence, Florence, Italy.
Tessa GoetghebuerDepartment of Pediatrics, Hôpital St Pierre, Université libre de Bruxelles, Bruxelles, Belgium.
Antoni Noguera-JulianInfectious Diseases and Systemic Inflammatory Response in Pediatrics, Infectious Diseases Unit, Department of Pediatrics, Sant Joan de Déu Hospital Research Foundation, Barcelona, Spain.
Laura C RodriguesDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Henriette ScherpbierEmma Children's Hospital/Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Colette SmitStichting HIV Monitoring, Amsterdam, The Netherlands.
Alasdair BamfordMRC Clinical Trials Unit at UCL, London, UK.
Siobhan CrichtonMRC Clinical Trials Unit at UCL, London, UK.
Marissa Luisa NavarroTranslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.
Jose T RamosDepartamento de Salud Pública y Materno-infantil, Universidad Complutense, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Josiane WarszawskiService d'Epidémiologie et Santé Publique, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Vana SpolouFirst Department of Paediatrics, Infectious Diseases Unit, "Agia Sophia" Childrens' Hospital, Athens, Greece.
Elena ChiappiniInfectious Disease Unit, Department of Health Sciences, Meyer Children's Hospital, University of Florence, Florence, Italy.ORCID 0000-0002-1476-4752
Elisabetta VenturiniInfectious Disease Unit, Department of Health Sciences, Meyer Children's Hospital, University of Florence, Florence, Italy.
Filipa PrataHospital de Santa Maria/CHULN, Lisbon, Portugal.
Christian KahlertChildren's Hospital of Eastern Switzerland and Cantonal Hospital, Infectious Diseases and Hospital Epidemiology, St Gallen, Switzerland.
Magdalena MarczynskaHospital of Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
Laura MarquesCentro Hospitalar e Universitário do Porto, Porto, Portugal.
Lars NaverKarolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Claire ThorneUniversity College London Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0003-0389-1956
Diana M GibbMRC Clinical Trials Unit at UCL, London, UK.
Carlo GiaquintoDepartment of Women and Child Health, University of Padova, Padova, Italy.
Ali JuddMRC Clinical Trials Unit at UCL, London, UK.ORCID 0000-0003-3176-5295
Intira Jeannie CollinsMRC Clinical Trials Unit at UCL, London, UK.
European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC)

Funding

Medical Research Council MC_UU_00004/03Medical Research Council MC_UU_12023/26
6 · The paper itself

Abstract

objectivesTo assess the effect of migrant status on treatment outcomes among children living with HIV in Europe.

methodsChildren aged < 18 years at the start of antiretroviral therapy (ART) in European paediatric HIV observational cohorts where ≥ 5% of children were migrants (defined as born abroad) were included. Three outcomes were considered: (i) severe immunosuppression-for-age; (ii) viraemic viral load (≥ 400 copies/mL) at 1 year after ART initiation; and (iii) AIDS/death after ART initiation. The effect of migrant status was assessed using univariable and multivariable logistic and Cox models.

resultsOf 2620 children included across 12 European countries, 56% were migrants. At ART initiation, migrant children were older than domestic-born children (median 6.1 vs. 0.9 years, p < 0.001), with slightly higher proportions being severely immunocompromised (35% vs. 33%) and with active tuberculosis (2% vs. 1%), but a lower proportion with an AIDS diagnosis (14% vs. 19%) (all p < 0.001). At 1 year after beginning ART, a lower proportion of migrant children were viraemic (18% vs. 24%) but there was no difference in multivariable analysis (p = 0.702), and no difference in severe immunosuppression (p = 0.409). However, there was a trend towards higher risk of AIDS/death in migrant children (adjusted hazard ratio = 1.51, 95% confidence interval: 0.96-2.38, p = 0.072).

conclusionsAfter adjusting for characteristics at ART initiation, migrant children have virological and immunological outcomes at 1 year of ART that are comparable to those who are domestic-born, possibly indicating equity in access to healthcare in Europe. However, there was some evidence of a difference in AIDS-free survival, which warrants further monitoring.

Indexed as

Anti-HIV AgentsHIV InfectionsTransients and MigrantsAdolescentChildEuropeHumansTreatment OutcomeViral LoadAnti-HIV AgentschildrenEuropeHIVmigrantmortality

Identifiers

PMID34596323
PMCPMC9293243

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.