ArticleAging cell2021
Ectopic cervical thymi and no thymic involution until midlife in naked mole rats.
Article in Aging cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Longevity through immunity: the unusual naked mole-rat immune system.GeroScience · 2026Review
- Immunometabolic resistors of aging in long-lived golden spiny mice.Science advances · 2026Article
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Features of the CD1 gene family in rodents and the uniqueness of the immune system of naked mole-rat.Biology direct · 2024Article
- Invariant γδTCR natural killer-like effector T cells in the naked mole-rat.Nature communications · 2024Article
- Evolution of T cells in the cancer-resistant naked mole-rat.Nature communications · 2024Article
- Article
- Innate Immunity and Phenoptosis.Biochemistry. Biokhimiia · 2022Article
- Carcinogenesis resistance in the longest-lived rodent, the naked mole-rat.Cancer science · 2022Review
- Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits.The EMBO journal · 2022Article
- Article
- Immune competence and spleen size scale with colony status in the naked mole-rat.Open biology · 2022Article
- Review
- Multiple thymi and no thymic involution in naked mole rats?Immunity & ageing : I & A · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Immunosenescence is a hallmark of aging and manifests as increased susceptibility to infection, autoimmunity, and cancer in the elderly. One component of immunosenescence is thymic involution, age-associated shrinkage of the thymus, observed in all vertebrates studied to date. The naked mole rat (Heterocephalus glaber) has become an attractive animal model in aging research due to its extreme longevity and resistance to disease. Here, we show that naked mole rats display no thymic involution up to 11 years of age. Furthermore, we found large ectopic cervical thymi in addition to the canonical thoracic thymus, both being identical in their cell composition. The developmental landscape in naked mole rat thymi revealed overt differences from the murine T-cell compartment, most notably a decrease of CD4
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.