Evidence map›Paper›PMID 34595823›Full record

ArticleEMBO reports2021

Mitochondrial F

Bettina Rieger, Tasnim Arroum, Marie-Theres Borowski, Jimmy Villalta, Karin B Busch

Erratum issuedAbstract read
In one paragraph

Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria.Protein science : a publication of the Protein Society · 2026
    Review
  10. Article
  11. ATP synthase activity boosts membrane proton acceptance and lateral diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Evaluation of metformin's effect on 5-fluorouracil-induced cardiotoxicity through cellular protection.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Article
  13. Article
  14. Organelles harbour pH gradients.Research square · 2026
    Article
  15. Review
  16. Organelles harbour pH gradients.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Review
  19. Mitochondrial Quality Control and Cell Death.International journal of molecular sciences · 2025
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Bettina RiegerInstitute of Molecular Cell Biology, School of Biology, University of Münster, Münster, Germany.
Tasnim ArroumInstitute of Molecular Cell Biology, School of Biology, University of Münster, Münster, Germany.ORCID 0000-0002-5452-709X
Marie-Theres BorowskiInstitute of Molecular Cell Biology, School of Biology, University of Münster, Münster, Germany.ORCID 0000-0003-3648-7757
Jimmy VillaltaInstitute of Molecular Cell Biology, School of Biology, University of Münster, Münster, Germany.ORCID 0000-0001-5235-4917
Karin B BuschInstitute of Molecular Cell Biology, School of Biology, University of Münster, Münster, Germany.ORCID 0000-0003-0525-0191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The classical view of oxidative phosphorylation is that a proton motive force (PMF) generated by the respiratory chain complexes fuels ATP synthesis via ATP synthase. Yet, under glycolytic conditions, ATP synthase in its reverse mode also can contribute to the PMF. Here, we dissected these two functions of ATP synthase and the role of its inhibitory factor 1 (IF1) under different metabolic conditions. pH profiles of mitochondrial sub-compartments were recorded with high spatial resolution in live mammalian cells by positioning a pH sensor directly at ATP synthase's F

Indexed as

Mitochondrial MembranesProton-Motive ForceAdenosine TriphosphateAnimalsMammalsMitochondriaOxidative PhosphorylationAdenosine TriphosphateIF1local pH measurementsMitochondrial F1FO ATP synthaseproton motive forceΔpH

Identifiers

PMID34595823
PMCPMC8647149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.