Evidence map›Paper›PMID 34595756›Full record

ArticleAnnals of neurology2021

LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis.

Omar K Siddiqi, Musie Ghebremichael, Kalo Musukuma, Xin Dang, Eugene Mubanga, Gretchen L Birbeck, Shawn Love, Clayton Buback, Barry Kosloff, Helen Ayles and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Omar K SiddiqiGlobal Neurology Program, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0001-9696-563X
Musie GhebremichaelHarvard Medical School and Ragon Institute of MGH, MIT, and Harvard, Boston, MA.
Kalo MusukumaDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Xin DangKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Eugene MubangaDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Gretchen L BirbeckDepartment of Neurology, University of Rochester, Rochester, NY.
Shawn LoveDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA.
Clayton BubackDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Barry KosloffZambart, Lusaka, Zambia.
Helen AylesZambart, Lusaka, Zambia.
Masharip AtadzhanovDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Igor J KoralnikKen & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0001-6836-1468
University of Zambia · ZMLondon School of Hygiene & Tropical Medicine · GBNorthwestern University · USBeth Israel Deaconess Medical Center · USHarvard University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity Teaching Hospital · ZM

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Novel CSF Diagnostics and Genotype Markers of Tuberculous Meningitis in ZambiaK23NS084054 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SIDDIQI, OMAR KHALIK · 2014 to 2018
$910k
NIH HHS P30AI 060354NINDS NIH HHS K23 NS084054NINDS NIH HHS K23NS084054
6 · The paper itself

Abstract

We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows: C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90:994-998.

Indexed as

GenotypeAdultEpoxide HydrolasesFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotidePrevalenceSurvival RateTuberculosis, MeningealYoung AdultZambiaEpoxide Hydrolasesleukotriene A4 hydrolase

Identifiers

PMID34595756
PMCPMC13273832
OpenAlexW3204933617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.