Evidence map›Paper›PMID 34595613›Full record

ArticleEuropean journal of pediatrics2022

Lower prevalence of congenital cytomegalovirus infection in Portugal: possible impact of COVID-19 lockdown?

Catarina Fernandez, Maria-Jesus Chasqueira, Augusta Marques, Lúcia Rodrigues, Mónica Marçal, Madalena Tuna, Mónica Cró Braz, Ana Serrão Neto, Cândida Mendes, David Lito and 6 more

Abstract read
In one paragraph

Article in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Congenital Cytomegalovirus Testing Outcomes From the ValEAR Trial.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Catarina FernandezCentro de Estudos de Doenças Crónicas, Faculdade de Ciências Médicas|NOVA Medical School, CEDOC, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Portugal.
Maria-Jesus ChasqueiraCentro de Estudos de Doenças Crónicas, Faculdade de Ciências Médicas|NOVA Medical School, CEDOC, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Portugal.
Augusta MarquesCentro de Estudos de Doenças Crónicas, Faculdade de Ciências Médicas|NOVA Medical School, CEDOC, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Portugal.
Lúcia RodriguesCentro de Estudos de Doenças Crónicas, Faculdade de Ciências Médicas|NOVA Medical School, CEDOC, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Portugal.
Mónica MarçalUnidade de Neonatologia-Serviço de Pediatria, Hospital São Francisco Xavier CHLO, Estrada Do Forte Do Alto Do Duque, 1449-005, Lisboa, Portugal.
Madalena TunaUnidade de Neonatologia-Serviço de Pediatria, Hospital São Francisco Xavier CHLO, Estrada Do Forte Do Alto Do Duque, 1449-005, Lisboa, Portugal.
Mónica Cró BrazServiço de Pediatria, Hospital CUF Descobertas, Rua Mário Botas, 1998-018, Lisboa, Portugal.
Ana Serrão NetoServiço de Pediatria, Hospital CUF Descobertas, Rua Mário Botas, 1998-018, Lisboa, Portugal.
Cândida MendesServiço de Pediatria, Hospital Vila Franca de Xira, Estrada Carlos Lima Costa no 2, 2600-009, Vila Franca de Xira, Portugal.
David LitoServiço de Pediatria, Hospital Vila Franca de Xira, Estrada Carlos Lima Costa no 2, 2600-009, Vila Franca de Xira, Portugal.
Paula RochaServiço de Pediatria, Hospital CUF Porto, Estrada da Circunvalação, 14341, 4100-180, Porto, Portugal.
Gabriela VasconcellosServiço de Pediatria, Hospital CUF Porto, Estrada da Circunvalação, 14341, 4100-180, Porto, Portugal.
Maria-Favila MenezesCentro de Medicina Laboratorial Germano de Sousa, Rua Cupertino de Miranda, 1600-513, Lisboa, Portugal.
Maria José SousaCentro de Medicina Laboratorial Germano de Sousa, Rua Cupertino de Miranda, 1600-513, Lisboa, Portugal.
Carla NunesCentro de Investigação Em Saúde Publica, Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa, Avenida Padre Cruz, 1600-560, Lisboa, Portugal.
Paulo PaixãoCentro de Estudos de Doenças Crónicas, Faculdade de Ciências Médicas|NOVA Medical School, CEDOC, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Portugal. paulo.paixao@nms.unl.pt.ORCID http://orcid.org/0000-0002-4294-0872

Funding

Merck Sharp & Dohme Corp., a division of Merck & Co., Inc., Kenilworth, NJ, USA IIS# 59301
6 · The paper itself

Abstract

Cytomegalovirus (CMV) is the most frequent cause of congenital infection all over the world. Its prevalence ranges from 0.2 to 2.2%. Transmission from children to their pregnant mothers is a well-known risk factor, particularly if they attend a childcare centre. This study aims to compare the prevalence of CMV congenital infection (CMV_CI) in Portugal (Lisbon) between two studies, performed respectively in 2019 and 2020. In the 2019 study, performed in two hospitals, we found a 0.67% CMV_CI prevalence, using a pool strategy previously tested with saliva samples. In the 2020 study, using the same pool approach in four hospitals (the previous and two additional), and based on 1277 samples, the prevalence was 0.078%.Conclusion: The close temporal coincidence with COVID-19 lockdown suggests that these measures may have had a significant impact on this reduction, although other explanations cannot be ruled-out. What is Known: • Cytomegalovirus is the leading cause of congenital infection. • Behavioural measures decrease cytomegalovirus seroconversion in pregnant women. What is New: • From 2019 to 2020 there was a significant reduction in the prevalence of congenital CMV infection.

Indexed as

COVID-19Cytomegalovirus InfectionsPregnancy Complications, InfectiousChildCommunicable Disease ControlFemaleHumansPortugalPregnancyPrevalenceSARS-CoV-2CMVCongenitalCOVID-19PoolsScreening

Identifiers

PMID34595613
PMCPMC8483795

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.