Evidence map›Paper›PMID 34595464›Full record

ArticleClinical hematology international2021

How to Simplify the Evaluation of Newly Introduced Chemotherapeutic Interventions in Myeloma.

Treen Carson Michael Morris, Mary B Drake, Paul J Kettle, Tracey McGuigan, Maeve Leahy, Michael O'Dwyer, Helen Enright, Tanya O'Shea, Rakesh Popat, Heather E Oakervee and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Clinical hematology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 2 countries.

Treen Carson Michael MorrisCentre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
Mary B DrakeDepartment of Haematology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, UK.
Paul J KettleDepartment of Haematology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, UK.
Tracey McGuiganDepartment of Haematology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, UK.
Maeve LeahyDepartment of Haematology, University Hospital Limerick, Limerick, Ireland.
Michael O'DwyerDepartment of Haematology, University Hospital Galway, Newcastle Road, Galway, Ireland.
Helen EnrightDepartment of Haematology, Tallaght Hospital, Dublin 24, Ireland.
Tanya O'SheaClinical Research Consulting Ltd., 16 College Square, Terenure, Dublin D6WF309, Ireland.
Rakesh PopatDepartment of Haematology, University College Hospital, London, UK.
Heather E OakerveeDepartment of Haematology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
Kwee YongDepartment of Haematology, University College Hospital, London, UK.
Jamie D CavenaghDepartment of Haematology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
David A CairnsLeeds Cancer Centre, St James's University Hospital, Leeds LS9 7TF, UK.
Alberto Alvarez-IglesiasDepartment of Haematology, University Hospital Galway, Newcastle Road, Galway, Ireland.
Gordon CookLeeds Cancer Centre, St James's University Hospital, Leeds LS9 7TF, UK.
St Bartholomew's Hospital · GBSt James's University Hospital · GBUniversity College London · GBUniversity Hospital Galway · IEUniversity of Ulster · GBAccenture (Ireland) · IEBelfast City Hospital · GBQueen's University Belfast · GBTallaght University Hospital · IEUniversity Hospital Limerick · IE

Funding

Cancer Research UK 25447
6 · The paper itself

Abstract

When the bortezomib [PS341], adriamycin and dexamethasone (PAD) regimen was first evaluated, the response rate in untreated patients was much superior to that elicited by conventional chemotherapeutic agents. We demonstrated the efficacy of PAD in relapsed or refractory patients by comparing the response rate obtained in 53 patients who received vincristine, adriamycin and dexamethasone (VAD) or equivalent regimen as induction therapy, using a comparative design in which each patient acted as their own control. Whereas 25 patients had a positive response to VAD, 37 patients had a response to PAD ≤ partial remission (PR) (

Indexed as

adriamycinbortezomibdexamethasoneMyelomaMyeloma XPADrelapseresponse

Identifiers

PMID34595464
PMCPMC8432324
OpenAlexW3128070364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.