Evidence map›Paper›PMID 34595440›Full record

ArticleClinical hematology international2020

Human Herpes Virus-6 Encephalitis Following Autologous Blood and Marrow Transplant.

Jacques Mario Azzi, Doyun Park, Maher Abdul-Hay, Kelli Cole, Frank Cirrone, Maxim Kreditor, A Samer Al-Homsi

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Clinical hematology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Uncovering the Cause of Pneumonia: Reactivation of HHV-6B in an Immunocompromised Patient.European journal of case reports in internal medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jacques Mario AzziDepartment of Medicine, New York University School of Medicine, New York, NY.
Doyun ParkDepartment of Medicine, New York University School of Medicine, New York, NY.
Maher Abdul-HayDepartment of Medicine, New York University School of Medicine, New York, NY.
Kelli ColeBlood and Marrow Transplantation, New York University Medical Center, New York, NY.
Frank CirroneBlood and Marrow Transplantation, New York University Medical Center, New York, NY.
Maxim KreditorDepartment of Medicine, New York University School of Medicine, New York, NY.
A Samer Al-HomsiDepartment of Medicine, New York University School of Medicine, New York, NY.
New York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human herpesvirus-6 (HHV-6) is a highly prevalent virus that establishes lifelong latency in human hosts. Symptomatic HHV-6 reactivation rarely occurs in immunocompetent individuals and is best described in immunosuppressed patients such as recipients of bone marrow transplants (BMT). In that setting, HHV-6 reactivation has been associated with fever, rash, pneumonitis, encephalitis, and delayed engraftment. While these complications are well documented in allogeneic transplant, the clinical impact of such reactivation is not well known in autologous BMT. We described a case of HHV-6-associated encephalitis in a previously heavily treated patient with multiple myeloma (MM) following a second autologous BMT, and discuss the need for clinicians to be aware of the potential clinical impact of HHV-6 following autologous BMT in the era of immunomodulatory agents.

Indexed as

Bone marrow transplantEncephalitisHuman herpes virus 6Multiple myeloma

Identifiers

PMID34595440
PMCPMC8432341
OpenAlexW2991353738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.