Evidence map›Paper›PMID 34595364›Full record

ArticleChronic stress (Thousand Oaks, Calif.)

Sex Differences in Peritraumatic Inflammatory Cytokines and Steroid Hormones Contribute to Prospective Risk for Nonremitting Posttraumatic Stress Disorder.

Chloe S Lalonde, Yara Mekawi, Kelly F Ethun, Eleonore Beurel, Felicia Gould, Firdaus S Dhabhar, Katharina Schultebraucks, Isaac Galatzer-Levy, Jessica L Maples-Keller, Barbara O Rothbaum and 4 more

Open access · goldAbstract read
In one paragraph

Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
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  9. Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Article
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  11. Review
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  16. Sex-dependent risk factors for PTSD: a prospective structural MRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Chloe S LalondeDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-6775-3299
Yara MekawiDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Kelly F EthunYerkes National Primate Research Center, Atlanta, Georgia, USA.
Eleonore BeurelDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Felicia GouldDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Firdaus S DhabharDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Katharina SchultebraucksDepartment of Emergency Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Isaac Galatzer-LevyDepartment of Psychiatry, New York University School of Medicine, New York, New York, USA.
Jessica L Maples-KellerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Barbara O RothbaumDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Charles B NemeroffDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, Dell Medical School, Austin, Texas, USA.ORCID https://orcid.org/0000-0001-7867-1160
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Vasiliki MichopoulosDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-2531-923X
Emory University · USUniversity of Miami · USColumbia University Irving Medical Center · USHarvard University · USThe University of Texas at Austin · USUniversity School · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
Emory University BIRCWH ProgramK12HD085850 · NICHD · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, STERK, CLAIRE E · 2015 to 2023
$4.4M
2 of 2 Prospective Determination of Psychobiological Risk Factors for PTSDR01MH094757 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2012 to 2016
$2.3M
1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSDR01MH094759 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI NEMEROFF, CHARLES B · 2012 to 2016
$1.8M
NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR002378NICHD NIH HHS K12 HD085850NIH HHS P51 OD011132NIMH NIH HHS R01 MH094757NIMH NIH HHS R01 MH094759
6 · The paper itself

Abstract

Women are at higher risk for developing posttraumatic stress disorder (PTSD) compared to men, yet little is known about the biological contributors to this sex difference. One possible mechanism is differential immunological and neuroendocrine responses to traumatic stress exposure. In the current prospective study, we aimed to identify whether sex is indirectly associated with the probability of developing nonremitting PTSD through pro-inflammatory markers and whether steroid hormone concentrations influence this effect. Female (

Indexed as

cytokineshormonesinflammationPTSDsex differencessteroids

Identifiers

PMID34595364
PMCPMC8477354
OpenAlexW3203313390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.