ArticleJournal of immunology research2021
Interleukin-6 versus Common Inflammatory Biomarkers for Diagnosing Fracture-Related Infection: Utility and Potential Influencing Factors.
Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Negative Pressure Wound Therapy and Ultrasound Monitoring for Fracture-Related Infection of the Proximal Femur: A Case Report.Infection and drug resistance · 2026Article
- Cephalomedullary Nailing vs. Dynamic Hip Screw for the Treatment of Pertrochanteric Fractures: The Role of Cytokines in the Prediction of Surgical Invasiveness.Journal of clinical medicine · 2025Article
- Microbiota shifts in fracture-related infections and pathogenic transitions identified by 16S rDNA sequencing.Scientific reports · 2025Article
- Future directions for early detection of fracture related infections.Journal of orthopaedics · 2024Article
- Fracture related Infection - Challenges in definition and diagnosis.Journal of orthopaedics · 2024Article
- Current Concepts of Fracture-Related Infection.International journal of clinical practice · 2023Review
- Article
- Retrospective Analysis of Infection Factors in Secondary Internal Fixation after External Fixation for Open Fracture of a Long Bone: A Cohort of 117 Patients in a Two-Center Clinical Study.BioMed research international · 2022Article
- In vitro and in vivo assessment of caprine origin Staphylococcus aureus ST398 strain UTCVM1 as an osteomyelitis pathogen.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Currently, the utility of white blood cell count (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), for diagnosis of fracture-related infection (FRI), is still controversial, and potential efficiency of interleukin-6 (IL-6) as a novel cytokine in assisted diagnosis of FRI remains unclear. This study is aimed at investigating the utility and potential influencing factors of IL-6 and the common biomarkers for diagnosing FRI. Preoperative serological levels of IL-6 and the three biomarkers were compared between 407 FRI patients and 195 fracture-healed (FH) patients. Diagnostic efficiency of the indicators was evaluated using the areas under the receiver operating characteristic (ROC) curves, and their potential influencing factors were also analyzed. Outcomes showed that the median levels of all of the four biomarkers were significantly higher among the FRI patients than those among the FH patients (
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