Evidence map›Paper›PMID 34595165›Full record

ArticleFrontiers in cell and developmental biology2021

Circular RNA CircPPP1CB Suppresses Tumorigenesis by Interacting With the MiR-1307-3p/SMG1 Axis in Human Bladder Cancer.

Feifan Wang, Yan Zhang, Xuejian Zhou, Xianwu Chen, Jiayong Xiang, Mengjing Fan, Yanlan Yu, Yueshu Cai, Hongshen Wu, Shihan Huang and 4 more

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  14. Research Progress of circRNAs in Glioblastoma.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Feifan WangDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yan ZhangDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xuejian ZhouDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xianwu ChenDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jiayong XiangDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Mengjing FanDepartment of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yanlan YuDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yueshu CaiDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hongshen WuDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shihan HuangDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ning HeDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhenghui HuDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Guoqing DingDepartment of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaodong JinDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) is a newly discovered endogenous non-coding RNA (ncRNA), which is characterized with a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selected circPPP1CB as a study object by circRNA sequencing and quantitative real-time PCR (qRT-PCR) validation in human bladder cancer (BC). CircPPP1CB is downregulated in BC and is negatively correlated with clinical stages and histological grades. Functionally, circPPP1CB modulated cell growth, metastasis, and epithelial-to-mesenchymal transition (EMT) process

Indexed as

bladder cancercircPPP1CBmiR-1307-3pSMG1tumorigenesis

Identifiers

PMID34595165
PMCPMC8476764

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.