Evidence map›Paper›PMID 34595130›Full record

ArticleFrontiers in cellular and infection microbiology2021

Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection.

Jane E Sinclair, Conor J Bloxham, Han Chiu, Keng Yih Chew, Jake Russell, Yusuke Yoshikawa, Helle Bielefeldt-Ohmann, Lauren E Steele, Katina D Hulme, Nathalie Aj Verzele and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Jane E SinclairSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Conor J BloxhamSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Han ChiuInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Keng Yih ChewSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Jake RussellSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Yusuke YoshikawaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Helle Bielefeldt-OhmannSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Lauren E SteeleSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Katina D HulmeSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Nathalie Aj VerzeleSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Ellesandra C NoyeSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Melanie WuSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Melissa E ReicheltSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Walter G ThomasSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Linda A GalloSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Meredith A ReddInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Kirsty R ShortSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-induced) diabetes model was employed to investigate influenza-induced cardiac distress. Lung histopathology and viral titres revealed no difference in respiratory severity between infected control and diabetic mice. However, compared with infected control mice, infected diabetic mice had increased serum cardiac troponin I and creatine-kinase MB, left ventricular structural changes and right ventricular functional alterations, providing the first experimental evidence of type I diabetes increasing risks of influenza-induced cardiovascular complications.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Influenza A virusInfluenza, HumanOrthomyxoviridae InfectionsAnimalsHumansMicecardiaccomorbidinfluenza A virusin vivomurine modeltype 1 diabetes mellitusvascular

Identifiers

PMID34595130
PMCPMC8476859
OpenAlexW3200951440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.