Evidence map›Paper›PMID 34595116›Full record

ArticleFrontiers in oncology2021

circRPS16 Promotes Proliferation and Invasion of Hepatocellular Carcinoma by Sponging miR-876-5p to Upregulate SPINK1.

Shuwen Lin, Ye Lin, Zhongshi Wu, Wuzheng Xia, Chenglong Miao, Tianyi Peng, Zhen Zhao, Chenggang Ji, Zhikang Mo, Xi Liu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Shuwen LinThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Ye LinDepartment of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhongshi WuThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Wuzheng XiaDepartment of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chenglong MiaoDepartment of General Surgery, Pizhou People's Hospital, Pizhou, China.
Tianyi PengDepartment of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhen ZhaoDepartment of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chenggang JiDepartment of General Surgery, Binhaiwan Central Hospital of Dongguan, (Also Called The Fifth People's Hospital of Dongguan), The Dongguan Affiliated Hospital of Medical College of Jinan University, Dongguan, China.
Zhikang MoDepartment of General Surgery, Binhaiwan Central Hospital of Dongguan, (Also Called The Fifth People's Hospital of Dongguan), The Dongguan Affiliated Hospital of Medical College of Jinan University, Dongguan, China.
Xi LiuDepartment of General Surgery, Binhaiwan Central Hospital of Dongguan, (Also Called The Fifth People's Hospital of Dongguan), The Dongguan Affiliated Hospital of Medical College of Jinan University, Dongguan, China.
Zhixiang JianThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Guangdong Academy of Medical Sciences · CNDongguan People’s Hospital · CNGuangdong Provincial People's Hospital · CNPeople's Hospital of Kaizhou District · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The roles of serine protease inhibitor Kazal type 1 (SPINK1) in multiple types of cancers have been significantly documented. However, its specific roles in hepatocellular carcinoma (HCC) remain to be investigated. This study found that SPINK1 is upregulated in HCC and its upregulation correlates with poor prognosis. Besides, functional assays revealed that SPINK1 promotes cell proliferation, cell cycle, and invasion

Indexed as

ceRNAcircRPS16hepatocellular carcinoma (HCC)invasionmiR-876-5pproliferationSPINK1

Identifiers

PMID34595116
PMCPMC8476860
OpenAlexW3201149415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.