Evidence map›Paper›PMID 34595090›Full record

ReviewAnalytical cellular pathology (Amsterdam)2021

Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer.

Zhifeng Li, Fujin Wang, Yinxing Zhu, Ting Guo, Mei Lin

Abstract readReview
In one paragraph

Review in Analytical cellular pathology (Amsterdam), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. The Advances in Epigenetics for Cancer Radiotherapy.International journal of molecular sciences · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhifeng LiDepartment of Oncology, Medical College of Nantong University, Nantong, 226001 Jiangsu, China.ORCID https://orcid.org/0000-0002-6141-5184
Fujin WangDepartment of Radiology, The First People's Hospital of Yancheng, Yancheng, 224006 Jiangsu, China.ORCID https://orcid.org/0000-0003-2504-4088
Yinxing ZhuTaizhou People's Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou, 225300 Jiangsu Province, China.ORCID https://orcid.org/0000-0002-7417-9109
Ting GuoResearch Center of Clinical Medicine, Taizhou People's Hospital (the Affiliated Hospital 5 of Nantong University), Taizhou, 225300 Jiangsu Province, China.ORCID https://orcid.org/0000-0002-3794-9346
Mei LinResearch Center of Clinical Medicine, Taizhou People's Hospital (the Affiliated Hospital 5 of Nantong University), Taizhou, 225300 Jiangsu Province, China.ORCID https://orcid.org/0000-0001-9815-2966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BRCA) has severely threatened women's health worldwide. Radiotherapy is a treatment for BRCA, which applies high doses of ionizing radiation to induce cancer cell death and reduce disease recurrence. Radioresistance is one of the most important elements that affect the therapeutic efficacy of radiotherapy. Long noncoding RNAs (lncRNAs) are suggested to dominate crucial roles in regulating the biological behavior of BRCA. Currently, some studies indicate that overexpression or inhibition of lncRNAs can greatly alter the radioresistance of BRCA. In this review, we summarized the knowledge on the classification and function of lncRNAs and the molecular mechanism of BRCA radioresistance, listed lncRNAs related to the BRCA radioresistance, highlighted their underlying mechanisms, and discussed the potential application of these lncRNAs in regulating BRCA radioresistance.

Indexed as

AnimalsBreast NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansRadiation ToleranceRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID34595090
PMCPMC8478560

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.