Evidence map›Paper›PMID 34594328›Full record

ArticleFrontiers in immunology2021

The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway.

Miho Takahashi, Yoshie Umehara, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 102 citations in OpenAlex.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Miho TakahashiAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Yoshie UmeharaAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hainan YueAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Juan Valentin Trujillo-PaezAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ge PengAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hai Le Thanh NguyenAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Risa IkutamaAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ko OkumuraAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hideoki OgawaAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Shigaku IkedaAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
François NiyonsabaAtopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Juntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to its antimicrobial activity, the skin-derived antimicrobial peptide human β-defensin-3 (hBD-3) promotes keratinocyte proliferation and migration to initiate the wound healing process; however, its effects on fibroblasts, which are the major cell type responsible for wound healing, remain unclear. We investigated the role of hBD-3 in cell migration, proliferation and production of angiogenic growth factors in human fibroblasts and evaluated the

Indexed as

Angiogenesis Inducing AgentsAnimalsAntimicrobial Peptidesbeta-DefensinsBiomarkersCell MovementCell ProliferationFibroblastsHumansJanus Kinase 2Matrix Metalloproteinase 2MiceModels, BiologicalPhosphorylationReceptors, Fibroblast Growth FactorSignal TransductionAngiogenesis Inducing AgentsAntimicrobial Peptidesbeta-DefensinsBiomarkersDEFB103A protein, humanJanus Kinase 2Matrix Metalloproteinase 2Receptors, Fibroblast Growth FactorSTAT3 protein, humanSTAT3 Transcription Factorangiogenesisfibroblasthuman β-defensinmigrationproliferationwound healing

Identifiers

PMID34594328
PMCPMC8476922
OpenAlexW3199440132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.