Evidence map›Paper›PMID 34594173›Full record

ArticleCase reports in gastroenterology

Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia.

Aiko Murayama, Kazuto Tajiri, Chiharu Kanegane, Jun Murakami, Yuka Hayashi, Ichiro Yasuda

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aiko MurayamaThe Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Kazuto TajiriThe Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Chiharu KaneganeDepartment of Pediatrics, National Hospital Organization Toyama Hospital, Toyama, Japan.
Jun MurakamiDivision of Transfusion Medicine and Cell Therapy, Toyama University Hospital, Toyama, Japan.
Yuka HayashiThe Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
Ichiro YasudaThe Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
University of Toyama · JPNational Hospital Organization · JPToyama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. At age 34 years, she was diagnosed with thrombocytopenia, probably associated with HCV infection. She showed refractory ascites for several months and was therefore administered crushed sofosbuvir/velpatasvir tablets via a nasal gastric tube. Her HCV infection was successfully eradicated, her ascites disappeared, and thrombocytopenia improved with a marked decrease in platelet-associated IgG.

Indexed as

Crushed administrationDecompensated cirrhosis CDirect-acting antiviralIntractable epilepsyThrombocytopenia

Identifiers

PMID34594173
PMCPMC8436629
OpenAlexW3196922137

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.