Evidence map›Paper›PMID 34593990›Full record

ArticleGene therapy2022

Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D

Aleksi J Leikas, Iiro Hassinen, Antti Hedman, Antti Kivelä, Seppo Ylä-Herttuala, Juha E K Hartikainen

Open access · hybridAbstract read
In one paragraph

Article in Gene therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Angiogenic Doping: Plausible Yet Difficult to Detect.Sports medicine (Auckland, N.Z.) · 2026
    Review
  3. [Gene doping: current test methods and analytical challenges].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026
    Review
  4. Chemical reviews · 2026
    Review
  5. Review
  6. Article
  7. Gene Therapy for Heart Failure.Journal of cardiovascular translational research · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Gene therapy then and now: A look back at changes in the field over the past 25 years.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aleksi J LeikasHeart Center, Kuopio University Hospital, Kuopio, Finland.ORCID 0000-0001-9590-0105
Iiro HassinenHeart Center, Kuopio University Hospital, Kuopio, Finland.
Antti HedmanHeart Center, Kuopio University Hospital, Kuopio, Finland.
Antti KiveläHeart Center, Kuopio University Hospital, Kuopio, Finland.
Seppo Ylä-HerttualaHeart Center, Kuopio University Hospital, Kuopio, Finland.
Juha E K HartikainenHeart Center, Kuopio University Hospital, Kuopio, Finland. juha.hartikainen@kuh.fi.ORCID 0000-0003-0847-107X
Kuopio University Hospital · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In phase I KAT301 trial, intramyocardial adenovirus-mediated vascular endothelial growth factor -D

Indexed as

AdenoviridaeAdenoviridae InfectionsAngina PectorisCanadaFollow-Up StudiesGenetic TherapyGene Transfer TechniquesHumansTreatment OutcomeVascular Endothelial Growth Factor AVascular Endothelial Growth Factor DVascular Endothelial Growth Factor AVascular Endothelial Growth Factor D

Identifiers

PMID34593990
PMCPMC9159942
OpenAlexW3203462303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.