Evidence map›Paper›PMID 34593915›Full record

ArticleScientific reports2021

COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19.

Luca Menestrina, Chiara Cabrelle, Maurizio Recanatini

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Luca MenestrinaDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126, Bologna, Italy.ORCID http://orcid.org/0000-0002-3397-7737
Chiara CabrelleDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126, Bologna, Italy.ORCID http://orcid.org/0000-0001-9518-5412
Maurizio RecanatiniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126, Bologna, Italy. maurizio.recanatini@unibo.it.ORCID http://orcid.org/0000-0002-0039-0518
University of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic poses a huge problem of public health that requires the implementation of all available means to contrast it, and drugs are one of them. In this context, we observed an unmet need of depicting the continuously evolving scenario of the ongoing drug clinical trials through an easy-to-use, freely accessible online tool. Starting from this consideration, we developed COVIDrugNet ( http://compmedchem.unibo.it/covidrugnet ), a web application that allows users to capture a holistic view and keep up to date on how the clinical drug research is responding to the SARS-CoV-2 infection. Here, we describe the web app and show through some examples how one can explore the whole landscape of medicines in clinical trial for the treatment of COVID-19 and try to probe the consistency of the current approaches with the available biological and pharmacological evidence. We conclude that careful analyses of the COVID-19 drug-target system based on COVIDrugNet can help to understand the biological implications of the proposed drug options, and eventually improve the search for more effective therapies.

Indexed as

COVID-19 Drug TreatmentClinical Trials as TopicComputational BiologyDatabases, PharmaceuticalDrug RepositioningHumansInternetViral ProteinsViral Proteins

Identifiers

PMID34593915
PMCPMC8484553
OpenAlexW3202636397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.