Evidence map›Paper›PMID 34593870›Full record

ArticleScientific reports2021

The immunomodulatory effects of long-term supplementation with Lactobacillus casei Shirota depend on ovalbumin presentation in BALB/c mice.

Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, Hui-Yu Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Immunomodulatory effects ofFrontiers in immunology · 2025
    Article
  3. Adjuvant Effect ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Li-Han ChenInstitute of Fisheries Science, National Taiwan University, Taipei, 10617, Taiwan.
Chun-Hsu PanSchool of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan.
Shih-Yi HuangGraduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, 11031, Taiwan.
Ching-Hung ChanDepartment of Chemical Engineering and Biotechnology, Tatung University, 10452, Taipei, Taiwan.
Hui-Yu HuangGraduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, 11031, Taiwan. maggieh323@hotmail.com.
Taipei Medical University · TWNational Taiwan University · TWTatung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunomodulation is an ability of several particular probiotics. However, it still remains unclear whether the immunomodulatory effects of specific probiotics vary for different antigen presentation models with the same antigen. To investigate this matter, six groups of BALB/c mice (n = 10) were exposed to one of two antigen presentation models: ovalbumin (OVA) by injection alone, or injection plus intranasal administration. Moreover, the mice were fed distilled water or Lactobacillus casei Shirota fermented beverage (LcSFB) at low (2.5 × 10

Indexed as

Antigen PresentationImmunityImmunomodulationAnimalsAntibody FormationCytokinesFermented BeveragesImmunophenotypingLacticaseibacillus caseiLymphocyte ActivationLymphocytesMiceMice, Inbred BALB COvalbuminProbioticsSpleenCytokinesOvalbumin

Identifiers

PMID34593870
PMCPMC8484482
OpenAlexW3204460412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.