Evidence map›Paper›PMID 34593865›Full record

ArticleScientific reports2021

Multifaceted empathy differences in children and adults with autism.

Jennifer M Quinde-Zlibut, Zachary J Williams, Madison Gerdes, Lisa E Mash, Brynna H Heflin, Carissa Cascio

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. A Scoping Review on Positive Emotions and Affect in Autism.Journal of autism and developmental disorders · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A sensorimotor basis for facial expressivity differences in autism.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  10. Article
  11. Article
  12. Individual differences in brain structure and self-reported empathy in children.Cognitive, affective & behavioral neuroscience · 2022
    Article
  13. Article
  14. Investigating the Relationship between Facial Mimicry and Empathy.Behavioral sciences (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Jennifer M Quinde-ZlibutVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA. Jennifer.m.quinde@vanderbilt.edu.
Zachary J WilliamsVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Madison GerdesGraduate Program in Criminology and Justice Policy, Northeastern University, Boston, MA, USA.
Lisa E MashSan Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA.
Brynna H HeflinGraduate Program in Clinical Psychology, Florida International University, Miami, FL, USA.
Carissa CascioVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Center for Autism and Related Disorders · USFlorida International University · USJohn F. Kennedy Center for the Performing Arts · USNortheastern University · USSan Diego State University · USVanderbilt University Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MIRNICS, KAROLY · 2015 to 2019
$7.1M
Training in Vision ResearchT32EY007135 · NEI · VANDERBILT UNIVERSITY · PI GEOFFREY F WOODMAN · 1994 to 2026
$5.8M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
Sensorimotor integration governing facial expression production in autism.R01MH102272 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASCIO, CARISSA J · 2014 to 2023
$4.3M
Peripersonal Space Representation as a Basis for Social Deficits in Autism and Schizophrenia Spectrum DisordersR21MH109225 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASCIO, CARISSA J, WALLACE, MARK THOMAS · 2016 to 2017
$435k
Advancing Opportunities for Ped. Research and the Role of CC-CHOC within NCATSU13TR000044 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KASKEL, FREDERICK JEFFREY · 2013 to 2013
$30k
Linking Clinical Translational Science Award Sites to Improve Pediatric ResearchR13TR000044 · NCATS · VANDERBILT UNIVERSITY · PI BARKIN, SHARI · 2012 to 2012
$23k
NCATS NIH HHS R13 TR000044NCATS NIH HHS U13 TR000044NEI NIH HHS T32 EY007135NICHD NIH HHS U54 HD083211NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIMH NIH HHS R01 MH102272NIMH NIH HHS R21 MH109225
6 · The paper itself

Abstract

Although empathy impairments have been reported in autistic individuals, there is no clear consensus on how emotional valence influences this multidimensional process. In this study, we use the Multifaceted Empathy Test for juveniles (MET-J) to interrogate emotional and cognitive empathy in 184 participants (ages 8-59 years, 83 autistic) under the robust Bayesian inference framework. Group comparisons demonstrate previously unreported interaction effects between: (1) valence and autism diagnosis in predictions of emotional resonance, and (2) valence and age group in predictions of arousal to images portraying positive and negative facial expressions. These results extend previous studies using the MET by examining differential effects of emotional valence in a large sample of autistic children and adults with average or above-average intelligence. We report impaired cognitive empathy in autism, and subtle differences in emotional empathy characterized by less distinction between emotional resonance to positive vs. negative facial expressions in autism compared to neurotypicals. Reduced emotional differentiation between positive and negative affect in others could be a mechanism for diminished social reciprocity that poses a universal challenge for people with autism. These component- and valence- specific findings are of clinical relevance for the development and implementation of target-specific social interventions in autism.

Indexed as

EmpathyAdolescentAdultArousalAutistic DisorderBayes TheoremCase-Control StudiesChildChild, PreschoolCognitionEmotionsHumansMaleSocial BehaviorYoung Adult

Identifiers

PMID34593865
PMCPMC8484273
OpenAlexW3164139416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.