ArticleScientific reports2021
Prospective association of air purifier use during pregnancy with the neurodevelopment of toddlers in the Japan Environment and Children's Study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Caesarean section may be associated with suspected motor developmental delay at 3 years of age in the Japan Environment and Children's Study.Scientific reports · 2026Article
- Association of air purifier usage during pregnancy with adverse birth outcomes: the Japan Environment and Children's Study.BMC public health · 2024Article
- Maternal dietary intake of fish and child neurodevelopment at 3 years: a nationwide birth cohort-The Japan Environment and Children's Study.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
5 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the association between maternal air purifier use during pregnancy and neurodevelopmental delay in toddlers by analysing data from 82,457 mother-toddler pairs. Air purifier use was measured using a simple yes/no question. Developmental delays at 1.5, 2.0, 2.5, and 3.0 years were assessed using the Ages and Stages Questionnaire, Third Edition. Generalized additive mixed model analysis with 21 covariates revealed that air purifier use was associated with lower prevalence of developmental delay in all five areas-communication, gross motor, fine motor, problem solving, and personal-social-at all four time points (adjusted risk ratios ranged from 0.827 to 0.927, and only one 95% confidence interval crossed the reference). These findings suggest a negative association between air purifier use during pregnancy and neurodevelopmental delay in toddlers.Trial registration: UMIN000030786 (15/01/2018).
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Registered trials
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