Evidence map›Paper›PMID 34593818›Full record

ArticleNature communications2021

Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells.

Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul M Mohammed, Sean Sun, Takanari Inoue, Rebecca Schulman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 citations in OpenAlex.

  1. Interactions of the DNA Nanostructure with Silane-Based Self-Assembled Monolayers.Langmuir : the ACS journal of surfaces and colloids · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Sisi JiaDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Siew Cheng PhuaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Yuta NihongakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0002-9818-9344
Yizeng LiDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Michael PacellaDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Yi LiDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Abdul M MohammedDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Sean SunDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Takanari InoueDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0002-7957-7624
Rebecca SchulmanDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA. rschulm3@jhu.edu.ORCID 0000-0003-4555-3162
Johns Hopkins University · USAgency for Science, Technology and Research · SG

Funding

The Role of Hydraulic Pressure in the Osmotic Engine Model of Cell MigrationR01GM134542 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SEAN X SUN · 2019 to 2026
$2.1M
Flow sensation by kidney cellsR01DK102910 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI INOUE, TAKANARI · 2014 to 2017
$1.6M
NIDDK NIH HHS R01 DK102910NIGMS NIH HHS R01 GM134542
6 · The paper itself

Abstract

Mesoscale molecular assemblies on the cell surface, such as cilia and filopodia, integrate information, control transport and amplify signals. Designer cell-surface assemblies could control these cellular functions. Such assemblies could be constructed from synthetic components ex vivo, making it possible to form such structures using modern nanoscale self-assembly and fabrication techniques, and then oriented on the cell surface. Here we integrate synthetic devices, micron-scale DNA nanotubes, with mammalian cells by anchoring them by their ends to specific cell surface receptors. These filaments can measure shear stresses between 0-2 dyn/cm

Indexed as

Biosensing TechniquesCell EngineeringDNAHEK293 CellsHeLa CellsHumansMicrotechnologyNanotubesStress, MechanicalDNA

Identifiers

PMID34593818
PMCPMC8484582
OpenAlexW3123876379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.