ArticleHorticulture research2021
The role of watermelon caffeic acid O-methyltransferase (ClCOMT1) in melatonin biosynthesis and abiotic stress tolerance.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Melatonin Induced Cold Tolerance in Plants: Physiological and Molecular Responses.Frontiers in plant science · 2022Pooled it
- Amelioration of cadmium toxicity in Vicia faba via modulation of caffeic acid O-methyltransferase gene expression by biochar and nanobiochar.Scientific reports · 2026Article
- The role of coumarin biosynthesis in modulating plant drought responses: insights from PpBMT overexpression in Arabidopsis.BMC plant biology · 2026Article
- Pseudomonads associated to salt-stressed plants facilitate stress adaption of soybean through enhanced lignin biosynthesis.Science advances · 2026Article
- Transcriptomic Analysis Suggests Shoots and Roots-Specific Antioxidant Responses to Early-/Long-Term Salt Stress inAntioxidants (Basel, Switzerland) · 2026Article
- Phytomelatonin as a key regulator of drought stress adaptation: signaling networks, microbial interactions, and biotechnological potential.Frontiers in plant science · 2026Review
- Review
- Natural Allelic Variations in IbCHYR1-IbZnFR Complex Regulate Fusarium Root Rot Resistance in Sweet Potato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Melatonin in crop plants: from biosynthesis through pleiotropic effects to enhanced stress resilience.Journal of applied genetics · 2025Review
- Comparative Genomic Analysis of COMT Family Genes in ThreePlants (Basel, Switzerland) · 2025Article
- Boosting drought resilience: the role of endophytic Bacillus safensis in enhancing melatonin production in chickpea cultivars.BMC plant biology · 2025Article
- MsbZIP55 regulates salinity tolerance by modulating melatonin biosynthesis in alfalfa.Plant biotechnology journal · 2025Article
- The transcription factor ClWRKY61 interacts with ClLEA55 to enhance salt tolerance in watermelon.Horticulture research · 2025Article
- DNA methylation confers epigenetic changes in cold-adapted microorganisms in response to cold stress.Extremophiles : life under extreme conditions · 2025Article
- Positive interaction between melatonin and methyl jasmonate enhancesFrontiers in plant science · 2025Article
- Exogenous Melatonin Boosts Heat Tolerance inPlants (Basel, Switzerland) · 2024Article
- Identification of GiOMT gene family in Glycyrrhiza inflata bat and expression analysis under UV-B stresses.BMC genomics · 2024Article
- Research Advancements in Salt Tolerance of Cucurbitaceae: From Salt Response to Molecular Mechanisms.International journal of molecular sciences · 2024Review
- Evolution and Analysis of Caffeic Acid Transferase (COMT) in Seed Plants.Biochemical genetics · 2024Article
- Caffeic AcidInternational journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin is a pleiotropic signaling molecule that regulates plant growth and responses to various abiotic stresses. The last step of melatonin synthesis in plants can be catalyzed by caffeic acid O-methyltransferase (COMT), a multifunctional enzyme reported to have N-acetylserotonin O-methyltransferase (ASMT) activity; however, the ASMT activity of COMT has not yet been characterized in nonmodel plants such as watermelon (Citrullus lanatus). Here, a total of 16 putative O-methyltransferase (ClOMT) genes were identified in watermelon. Among them, ClOMT03 (Cla97C07G144540) was considered a potential COMT gene (renamed ClCOMT1) based on its high identities (60.00-74.93%) to known COMT genes involved in melatonin biosynthesis, expression in almost all tissues, and upregulation under abiotic stresses. The ClCOMT1 protein was localized in the cytoplasm. Overexpression of ClCOMT1 significantly increased melatonin contents, while ClCOMT1 knockout using the CRISPR/Cas-9 system decreased melatonin contents in watermelon calli. These results suggest that ClCOMT1 plays an essential role in melatonin biosynthesis in watermelon. In addition, ClCOMT1 expression in watermelon was upregulated by cold, drought, and salt stress, accompanied by increases in melatonin contents. Overexpression of ClCOMT1 enhanced transgenic Arabidopsis tolerance against such abiotic stresses, indicating that ClCOMT1 is a positive regulator of plant tolerance to abiotic stresses.
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